Students will participate in a research project related to the research of Dr. Tin Tin Su. The aim of the project is to identify novel chemotherapeutics that produce additive or synergistic effects with radiation by screening in fruit flies (Drosophila
). Based on prior experience, we expect students to screen through and analyze data from approximately 400 compounds total. The experiment, from embryo collection to data analysis, takes approximately three weeks (collect embryos on day 0, irradiate larvae on day 5, determine genotypes using fluorescence microscopy on day 15, and quantify survival on day 20). The overriding goal of MCDB 2171 is for students to become familiar with a number of biology concepts and techniques including model systems, genetics (inherent statistics, autosomal mutations, maternal effects, balancer chromosomes), approaches to screening for new cancer therapeutics, statistical analyses, and compound validation. Unlike laboratory exercises that are designed to reinforce concepts that may accompany lecture topics, there is no certainty that any one particular project will succeed, which mirrors the inherent risks of novel research. The goal-oriented nature of this research effort means that validation of findings will also need to be performed. Notes
: This 2 credit course is offered spring semesters. Recommended corequisite courses of MCDB 2150 or EBIO 1220.
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