News

It's been a productive few months, with eleven new publications since our last update in February. A quick overview of these articles: At the beginning of March, group alumnus Ben Carberry's final manuscript was published in Macromolecules . In this work, he elucidated the degradation kinetics of thioester-crosslinked hydrogels and...

Postdoc Michael Blatchley and group alumnus Arda Günay recently published a new approach for expansion microscopy of organoids in Advanced Materials . In this work, they utilize the covalent adaptable allyl sulfide chemistry to exchange fluorescently labeled biomolecules between an initial gel used for tissue clearing with an expandable gel...

Congratulations to authors Jason Silver (former MD-PhD student) and Arda Günay (former postdoc), as well as Benjamin Carberry and Max Yavitt (current graduate students) for their respective publications in Biomaterials and Biofabrication. Read more from Jason and Arda about how BAG3 and the Hippo pathway control myoblast mechanotransduction and YAP/TAZ...

Recent graduate Cierra Walker, postdoc Megan Schroeder, and newly-minted UCSD assistant professor Brian Aguado were published in the Journal of Molecular and Cellular Cardiology last month. Their review, "Matters of the heart," covers important differences between male and female cardiac cells that result in sexually dimorphic pathogenesis and disease progression...

Graduate student Cierra Walker published today in Nature Biomedical Engineering , reporting on chromatin remodeling in response to dynamic changes in substrate modulus. Additionally, Cierra showed that chromatin is more condensed in the myofibroblasts of human patients with aortic valve stenosis compared to healthy controls. Learn more at the journal...

Congratulations to postdoctoral researcher Laura Macdougall and graduate student Bruce Kirkpatrick for the release of their new article " Photoclick Chemistry: A Bright Idea." Along with authors from the Bowman lab, Laura and Bruce review photo-catalyzed click reactions and their applications — read more at the journal site .

Varsha Rao and recently-graduated Dr. Alex Caldwell published this month in Bioengineering & Translational Medicine , utilizing their bio-click porous microgel scaffolds to co-culture hMSCs with macrophages (and subsequently control macrophage phenotypes). Learn more at the journal site: https://doi.org/10.1002/btm2.10217 .

Congratulations to recent doctorate recipient Benjamin Richardson and current graduate student Cierra Walker, who published yesterday in Advanced Healthcare Materials on using dynamic compression bioreactors and viscoelastic culture matrices to recapitulate the load-bearing and stress-relaxing 3D nature of native cartilaginous tissue. Read more at the journal site.

Following his outstanding recent thesis defense, graduate student Dr. Jason Silver (alongside postdoctoral researcher Dr. Arda Günay) published this week in Science Advances on YAP/TAZ mechanotransduction-mediated activation of muscle satellite cells following injury. ( Read the full article. )

Graduate student Varsha Rao won the CU Boulder Three Minute Thesis Competition on February 16th. Her entry, "Movie Sets for Cells," captivated the judges and audience alike for its remarkable distillation of the intricacies of intercellular signaling at sites of repair and regeneration in the body (in just 180 seconds!);...