Quiescent fibroblasts activate to transient myofibroblasts on stiff matrices.

Cierra elucidates mechanical contributions to epigenetic changes in aortic valve disease

April 19, 2021

Graduate student Cierra Walker published today in Nature Biomedical Engineering , reporting on chromatin remodeling in response to dynamic changes in substrate modulus. Additionally, Cierra showed that chromatin is more condensed in the myofibroblasts of human patients with aortic valve stenosis compared to healthy controls. Learn more at the journal...

Photoclick chemistries

Laura and Bruce publish on photoclick chemistry in Chemical Reviews

April 9, 2021

Congratulations to postdoctoral researcher Laura Macdougall and graduate student Bruce Kirkpatrick for the release of their new article " Photoclick Chemistry: A Bright Idea." Along with authors from the Bowman lab, Laura and Bruce review photo-catalyzed click reactions and their applications — read more at the journal site .

MSC-macrophage-microgels

Varsha demonstrates macrophage polarization control using hMSC-inspired microgel scaffolds

March 23, 2021

Varsha Rao and recently-graduated Dr. Alex Caldwell published this month in Bioengineering & Translational Medicine , utilizing their bio-click porous microgel scaffolds to co-culture hMSCs with macrophages (and subsequently control macrophage phenotypes). Learn more at the journal site: https://doi.org/10.1002/btm2.10217 .

Dynamic loading schematic

Ben Richardson and Cierra investigate the effects of dynamic loading and viscoelastic matrices on chondrocytes

March 19, 2021

Congratulations to recent doctorate recipient Benjamin Richardson and current graduate student Cierra Walker, who published yesterday in Advanced Healthcare Materials on using dynamic compression bioreactors and viscoelastic culture matrices to recapitulate the load-bearing and stress-relaxing 3D nature of native cartilaginous tissue. Read more at the journal site.

Muscle stiffening induces YAP/TAZ localization

Jason and Arda publish on muscle mechanobiology in Science Advances

March 16, 2021

Following his outstanding recent thesis defense, graduate student Dr. Jason Silver (alongside postdoctoral researcher Dr. Arda Günay) published this week in Science Advances on YAP/TAZ mechanotransduction-mediated activation of muscle satellite cells following injury. ( Read the full article. )

Varsha's award-winning 3-minute thesis slide

Congratulations to Varsha for taking first place in the 2021 CU Boulder Three Minute Thesis Competition!

Feb. 25, 2021

Graduate student Varsha Rao won the CU Boulder Three Minute Thesis Competition on February 16th. Her entry, "Movie Sets for Cells," captivated the judges and audience alike for its remarkable distillation of the intricacies of intercellular signaling at sites of repair and regeneration in the body (in just 180 seconds!);...

FASEB 2021 figure

Megan and Cierra investigate myofibroblast TNFa signaling in FASEB

Feb. 18, 2021

Congratulations to group alumni Drs. Andrea Gonzalez Rodriguez and Joe Grim, along with current postdoc Megan Schroeder and graduate student Cierra Walker, who published recently in The FASEB Journal on their work describing TFNa-mediated myofibroblast calcification. Read more.

Engineering the MSC Secretome: A Hydrogel Focused Approach

Varsha and Ali review strategies for engineering the MSC secretome in Advanced Healthcare Materials!

Feb. 17, 2021

Congratulations to Varsha, Ali, and group alumna Dr. Marissa Wechsler for their new publication in Advanced Healthcare Materials , "Engineering the MSC Secretome: A Hydrogel Focused Approach." Read more: https://doi.org/10.1002/adhm.202001948 .

Anionic nanogels protect high pI proteins.

Laura publishes on nanogels and protein protection in ACS Biomaterials Science & Engineering!

Feb. 9, 2021

Postdoc Dr. Laura Macdougall and alumna Dr. Marissa Wechsler are co-first authors on the latest publication from our group: "Charged Poly(N-isopropylacrylamide) Nanogels for the Stabilization of High Isoelectric Point Proteins" was published today in ACS Biomaterials Science & Engineering. Read more here .

Brian Aguado took 3rd place in the 2020 Biofrontiers Up-Close Image Competition.

Congratulations to Brian, Megan, and Varsha for their award-winning entries in the Biofrontiers Up-Close Image Competition!

Jan. 3, 2021

To close 2020, we're thrilled to congratulate postdoctoral researcher Brian Aguado for being awarded 3rd place in the annual Biofrontiers Up-Close Image Competition. Additionally, postdoc Megan Schroeder and graduate student Varsha Rao both received honorable mentions for their submissions.

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