I work with intestinal organoids and seek to develop methods to characterize and control cell-matrix interactions to understand and guide tissue morphogenesis. I’m specifically interested in the role of the extracellular matrix in symmetry breaking events and how tissue form informs cell fate decisions. I’ll be starting my own lab in the Spring of 2024 at Syracuse University (website coming soon!).
Besides pipetting, I enjoy hiking with my wife, daughter, and dog, as well as trail running, biking, and skiing.
Left – Photo-expansion microscopy (PhotoExM) enables sub-micron resolution imaging of organoids embedded in Matrigel or synthetic hydrogels. Middle – Photopatterning via photosoftening of synthetic matrices facilitates the formation of deterministic crypt structures in iPSC-derived intestinal organoids. Right – Non-canonical amino acid tagging can be used to track the deposition of extracellular proteins produced by the cells comprising organoids.