Updated 2/19/2015 10:18 AM

ASEN 5016

Spring 2015

Tues/Thurs 2-3:15 pm

Instructor: Dr. David Klaus

telephone: (303) 492-3525

email: klaus@colorado.edu


This course is primarily intended to familiarize engineering students with factors affecting living organisms (ranging from single cells to humans) in the reduced-gravity environment of space flight, including lunar and Martian surface conditions. Unique insight will be gained regarding engineering design requirements for spacecraft habitats, life support systems and spacesuits, as well as space biology payloads. Life support fundamentals, as they relate to basic human survival requirements, are covered initially. Next, the lectures turn to more detailed descriptions of the physiological adaptations that occur to people in space, with pertinent background information presented for each topic. Corresponding biomedical countermeasures needed to maintain crew health for long duration missions will also be discussed, including future Moon and Mars exploration. Finally, the underlying biophysical mechanisms affected by gravity, along with experiment design criteria, will be addressed.  Current events within NASA’s future exploration mission programs and the emerging commercial human space flight sector are reflected throughout the lecture topics.


To further elaborate on the lecture material presented in class, a series of integrated homework tasks provides a practical introduction to the process of journal article publishing and research proposal writing, including the peer review process used for each. The assignment begins with writing a short journal article on a relevant topic of your choice, participating as a peer reviewer for the editor, revising your draft per the review comments you receive back, and submitting a final manuscript.  From this background, you will subsequently prepare a research grant proposal that builds on your selected topic (along with a CV and budget) and culminates in a mock review panel. This end-to-end flow closely mimics the standard practice in the scientific community and is a valuable generic process to experience regardless of your specific research interests.



Lecture access is available through CAETE http://cuengineeringonline.colorado.edu


Lecture notes are posted on D2L https://learn.colorado.edu



LECTURE TOPICS (order and topics subject to slight revision)

Overview of Humans in Space

Course Overview & Historical Perspectives on Human Space Flight

Relevant Space Flight Environmental Parameters

Human Spacecraft Life Support Requirements and Considerations

Respiration and the Oxygen Cascade

Nutrition – Ch. 8 & Temperature Regulation

Gravity Dependent Physical Processes

Motor Control & Chronobiology

Human Performance in Space

Wrap up / Exam Review

Exam 1 - 2/12/15

Human Physiological Adaptations to Space Flight

Guest Speaker, NASA Astronaut Steve Swanson

Physiology of Extravehicular Activity (EVA) – Ch. 5

Miscellaneous Human Physiological Responses to Space Flight

Hormonal Regulation / Immunological Response

Neuro-Sensory System – Ch. 6 (balance) & Ch. 9 (motion sickness)

Cardiovascular System – Ch. 7

Skeletal System – Ch. 1

Muscular System – Ch. 4

Wrap up / Exam Review

Exam 2 – 3/19/14


-- Spring Break Week 3/23-27

Space Life Science Research

Operational Space Medicine – Ch. 12 (partial)

Microbial Responses & Related Crew Health Issues

Space Biotechnology

Space Biology Experiment Design & Proposal Writing

0g & 1g Analogs (Earth-based and Space-based)

Radiation Effects – Ch. 3

Summary of Current Biomedical Countermeasures – Ch. 11 & 12 (partial)

Plant and Animal Research in Space

Psycho-Sociological Aspects – Ch. 2

Astrobiology / Mock Review Panel prep / Course wrap up


Mock Review Panel – Final Exam Period: Weds May 6, 2015 from 1:30 p.m. – 4:00 p.m.


GRADING      20% - Exam 1

20% - Exam 2

10% - Quizzes (take home and in class)


20% - Homework 1, Review Article – grade based on final ‘revised and resubmitted’ version following peer review

  5% - Homework 2, Journal Peer Review – your evaluation as a reviewer

20% - Homework 3, Research Proposal – grade based on proposal submittal with consideration of reviewer comments

  5% - Homework 4, Proposal Peer Review – your evaluation as a reviewer and participation in the ‘Mock Panel Meeting’


HW1 Review Article assigned – 1/20

HW1 Topic Selection due – 1/29


HW1 Annotated Bibliography / Working Title due – 2/10

HW3 Research RFP with Submission Guidelines assigned – 2/17 2/19

HW1 Manuscript Submittal (one hardcopy and electronic file) with Cover Letter due – 2/24

HW2 Journal Peer Review Process with Reviewer Instructions and Evaluation Metrics assigned – 2/26


HW2 Reviewer Comments / Score Sheets due – 3/5

HW3 Research Proposal NOI due (topic only) – 3/10

HW2 Reviewer Comments / Interim Score Returned to Authors – 3/12

HW3 Proposal Budget and CV prep – 3/17 (in class discussion, no deliverables)


HW1 Final Manuscript with Cover Letter – due 4/2

HW3 Research Proposal (hardcopy and electronic) due – 4/14

HW4 Proposal Review Process (Evaluation Metrics) assigned – 4/16

HW4 Reviewer Score Sheets (hardcopy and electronic for local students, e-copy only for CAETE) due – 4/23

HW4 Mock Review Panel assigned – 4/28 (NOTE: for this exercise, CAETE students are on the same schedule as the local class)


HW4 Mock Review Panel Meeting – Final Exam Period (Weds 5/6 1:30-4 pm)







TEXT               Space Physiology, Buckey, Oxford University Press, 2006 (required)


Ancillary references for additional information on this field of study (not required)

Textbook of Medical Physiology, 12th ed. Guyton and Hall, 2011

Fundamentals of Aerospace Medicine, 4th ed., Dehart and Davis, 2008


Going Higher – Oxygen, Man and Mountains, 5th ed., Houston, 2005

Fundamentals of Space Medicine, Clement, Kluwer Academic Press, 2003


Space Physiology and Medicine, 3rd ed., Nicogossian, Huntoon and Pool, 1994 (out of print, difficult to find)

Bioastronautics Data Book, 2nd ed., Parker and West (eds.), NASA SP-3006, 1973 (1st ed., 1964, both are out of print, difficult to find)


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