Profile Picture of Loren Hough
Assistant Professor
Physics
(303) 735-0529

Office 1: DUAN F529, Duane Physics Tower

Office 2: D214, JSC Biotech Bldg

Lab: Located in JSCBB C wing, 2nd floor

Research

I currently study intrinsically disordered proteins using solution NMR. Proteins containing disordered domains perform many important cellular functions. The aggregations of some members of this family of proteins is implicated in neuodegenerative diseases such as Alzheimer's and Parkinson's diseases.  My lab currently has two main projects, one to dissect the role of tubulin's C-terminal tail in microtubule structure and functions.  The second focuses on selective transport through the nuclear pore complex.  We are use microscopy, nuclear magentic resonance and other biophysical techniques complemented with modeling to approach these systems.  This work includes using in cell NMR, a technique to study the structure and dynamics of proteins within living cells.

Education

  • PhD Physics, University of Colorado Boulder, 2007
  • Graduate work, University of California Santa Barbara, 2001-2002
  • BA Physics, magna cum laude with highest honors, Harvard University, 2000

Honors and Awards

  • Boettcher Investigator in the Webb-Waring Biomedical Research Program
  • Charles H. Revson Fellowship in Life Sciences, 2010
  • NIH Ruth L. Kirschstein National Research Service Postdoctoral Fellowship, 2009
  • Glenn Brown Prize, International Liquid Crystal Society, 2008
  • Trainee, NIH Biophysics Training Grant (T32-CU Boulder), 2006-2007
  • GAANN Fellowship, Liquid Crystal Materials Research Center, CU Boulder, 2005-2006
  • NSF Graduate Research Fellowship, 2002-2005
  • Broida and GAANN Fellowships, Physics Department, UC Santa Barbara 2001-2002
  • Phi Beta Kappa, 2000
  • Barry Goldwater Scholarship, 1998

Outreach