Dr. Stitzel is an Associate Professor in the
Department of Integrative Physiology and a Faculty Fellow
at the Institute for Behavioral Genetics. He received his
Ph.D. from The Johns Hopkins University in 1992. Dr. Stitzel’s
primary research interest is the use of genetic strategies
to identify the underlying molecular and cellular bases for
the behavioral and physiological actions of nicotine and other
drugs of abuse. A second area of interest of the laboratory
is in understanding the neurobiological substrates that are
responsible for daily variations in sensitivity to the behavioral
and physiological effects of nicotine. A wide repertoire of
methods are utilized in Dr. Stitzel’s laboratory, ranging
from standard molecular techniques, biochemical methods, and
cell culture approaches to behavioral and physiological testing
of standard and genetically manipulated mice. The research
in Dr. Stitzel’s lab has been supported by the NIH (National
Institute on Drug Abuse, National Institute of Mental Health
and National Cancer Institute), The American Cancer Society,
and The Alcoholic Beverage Medical Research Foundation.
Hoft NR, Stitzel JA, Hutchison KE, and Ehringer MA. 2011. CHRNB2 Promoter Region: Association with subjective effects to nicotine and gene expression differences. Genes Brain and Behavior 10:176-85.
Papke RL, Wecker L and Stitzel JA. 2010. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 333:501-518.
Wilking JA, Hesterburg K, Crouch EL, Homanics G, and Stitzel JA. 2010. The mouse Chrna4 T529A polymorphism influences nicotine reinforcement and nicotinic receptor function. Pharmacogenetics and Genomics 20:121-130.
Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WH, Breslau N, Budde J, Cloninger CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman S, Madden PAF, Mayo K, Nurnberger J, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G, Tischfield JA, Edenberg HJ, Rice JP, Goete AM. 2008. Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry. 165:1163-71.