Russell L. Moore

Integrative Physiology; Medicine (Cardiology); Member of the Center for Neuroscience

Department of Integrative Physiology
Campus Box 354
Carlson 202D
University of Colorado at Boulder
Boulder,CO 80309-0354

Email: rmoore@spot.colorado.edu
Phone: 303-492-5209
FAX: 303-492-6778
Website: http://www.Colorado.EDU/kines/faculty/moore.html
Lab Website: http://www.Colorado.EDU/kines/research/cell.html

Dr. Moore's laboratory is involved in determining the cellular basis for alterations in intrinsic cardiac contractile function in response to certain physiological (exercise training) and pathophysiogical (advanced aging, heart failure) stresses. A central focus of the laboratory is on myocardial Ca2+ regulation, and processes that are thought to directly regulate and/or modulate sarcoreticular and transarcolemmal Ca2+ movement. Studies are ongoing to determine how aging and exercise training affect myocardial sodium-calcium exchange, and the protein expression and function of a variety of voltage-regulated K+ channels. Another key area of interest is on the potential roles of cardiac sarcolemmal and mitochondrial ATP-sensitive K+ channels in exercise training-induced protection of the heart against ischemia-reperfusion injury. Work in Dr. Moore's laboratory is supported by grants from the NIH (National Institute on Aging; National Heart, Lung, Blood Institute) and the American Heart Association.

Dr. Moore is a Professor of Kinesiology and Applied Physiology and Medicine (Adjunct in Cardiology, UCHSC). He currently serves an Associate Editor of the Journal of Applied Physiology and Exercise and Sport Sciences Reviews. Since 1990, he has served as both a regular and ad hoc grant reviewer for the National Institutes of Health, American Heart Association, National Sciences and Engineering Research Council (Canada).

Selected Publications:

Snyder, SM, BM Palmer, and RL Moore. A mathematical model of cardiocyte Ca2+ dynamics with a novel representation of sarcoplasmic reticular Ca2+ control. Biophysical J. 79(1):94-115, 2000.

Palmer, BM and RL Moore. Excitation wavelengths for fura 2 provide a linear relationship between [Ca2+] and fluorescence ratio. Am. J. Physiol. Cell Physiol. 279:C1278-C1284, 2000.

Olsson, M.C. ,B.M. Palmer, L.A. Leinwand, and R.L. Moore. Gender and aging in a transgenic model of hypertrophic cardiomyopathy. Am.J.Physiol.:Heart Circ. Physiol., 280:H1136-H1144, 2001.

Jew, K.N., M.C. Olsson, E.A. Mokelke, B.M. Palmer, and R.L. Moore. Endurance training alters outward K+ current characteristics in rat cardiocytes. J. Appl. Physiol., 90:1327-1333, 2001.

Jew, K.N. and R.L. Moore. Glibenclamide improves post-ischemic recovery of myocardial contractile function in trained and sedentary rats. J. Appl. Physiol. 1545-1554, 2001.

Jew, K.N. and R.L. Moore. Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes. J. Appl. Physiol.. 92:1473-1479, 2002.