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Dr. Pei-San Tsai is an associate professor of Integrative
Physiology at the University of Colorado, Boulder. She received
her B.S. from Texas A&M University, and both her M.A.
and Ph.D. from the University of California at Berkeley. Dr.
Tsai's research focuses on the evolution of the structure
and function of gonadotropin-releasing hormone (GnRH), a neurohormone
that is central to the initiation and maintenance of reproduction
in vertebrates, and the development of a small population
of neurons that synthesize GnRH. Current efforts involve the
utilization of molecular, cellular, and physiological techniques
and various vertebrate and invertebrate models to study the
biology of GnRH.
Selected Publications:
P-S Tsai and L Zhang (2008). The emergence and loss of gonadotropin-releasing
hormone (GnRH) in protostomes: Orthology, phylogeny, structure,
and function. Biol Reprod, in press.
WC Chung, SS Moyle and P-S Tsai (2008). Fibroblast growth
factor 8 signaling through FGF receptor 1 is required for
the emergence of gonadotropin-releasing hormone neurons. Endocrinology,
in press.
J Falardeau, WC Chung, A Beekeen, L Plummer, Y Sidis, T Raivio,
A Dwyer, S Na, J Hall, C Huot, N Alois, R Quinton, L W Cole,
V Hughes, M Mohammadi,P-S Tsai and N Pitteloud (2008).Decreased
FGF8 signaling causes GnRH deficiency in human and mice. J
Clin Invest 118:2822-2831.
L Zhang, JA Tello, W Zhang and P-S Tsai (2008). Molecular
cloning, expression pattern, and immunocytochemical localization
of a gonadotropin-releasing hormone-like molecule in the gastropod
mollusk, Aplysia californica. Gen Comp Endocrinol 156:201-209.
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