| Dr. Stitzel is an Assistant Professor in the
Department of Integrative Physiology and a Faculty Fellow
at the Institute for Behavioral Genetics. He received his
Ph.D. from The Johns Hopkins University in 1992. Dr. Stitzel’s
primary research interest is the use of genetic strategies
to identify the underlying molecular and cellular bases for
the behavioral and physiological actions of nicotine and other
drugs of abuse. A second area of interest of the laboratory
is in understanding the neurobiological substrates that are
responsible for daily variations in sensitivity to the behavioral
and physiological effects of nicotine. A wide repertoire of
methods are utilized in Dr. Stitzel’s laboratory, ranging
from standard molecular techniques, biochemical methods, and
cell culture approaches to behavioral and physiological testing
of standard and genetically manipulated mice. The research
in Dr. Stitzel’s lab has been supported by the NIH (National
Institute on Drug Abuse, National Institute of Mental Health
and National Cancer Institute), The American Cancer Society,
and The Alcoholic Beverage Medical Research Foundation.
Selected Publications:
Stitzel JA. 2008. Naturally-occurring genetic variability
in the nicotinic acetylcholine receptor alpha4 and alpha7
subunit genes and phenotypic diversity in humans and mice.
Front Biosci. 13:477-91
Mexal S, Jenkins PM, Lautner MA, Iacob E, Crouch EL, Stitzel
JA. 2007. alpha7 nicotinic receptor gene promoter polymorphisms
in inbred mice affect expression in a cell type-specific fashion.
J. Biol. Chem. 282:13220-7
Li XC, Karadsheh MS, Jenkins PM, Brooks JC, Drapeau JA, Shah
MS, Lautner MA, Stitzel JA. 2007. Chromosomal loci that influence
oral nicotine consumption in C57BL/6J x C3H/HeJ F2 intercross
mice. Genes Brain Behav. 6:401-10
Adams CE, Yonchek JC, Stitzel JA. 2006. Development of hippocampal
alpha7 nicotinic receptors in C3H and DBA/2 congenic mice.
Brain Res. 1122:27-35
|
