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Jacqueline E. Lee
Molecular, Cellular & Developmental Biology; Member of
the Center for Neuroscience
Department of Molecular, Cellular & Developmental
Biology, Campus Box 347
MCDB Addition A245C
University of Colorado at Boulder
Boulder, CO 80309-0347
email: Jackie.Lee@colorado.edu
Phone: 303-492-6703
FAX: 303-492-7744
Website: http://mcdb.colorado.edu/faculty/lee99.html
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Dr. Lee received her B.S. in Molecular Biology from the University
of Wisconsin at Madison in 1985 and Ph.D. in Genetics and
Development from Columbia University in New York in 1991.
After completing her postdoctoral work with Dr. Harold Weintraub
at the Fred Hutchinson Cancer Research Center, Seattle, WA,
she had been a faculty member in the Department of Pediatrics
at the University of Colorado Health Sciences Center for two
years before moving to the University of Colorado at Boulder.
During her postdoctoral work, she discovered NeuroD, a trancription
factor capable of converting embryonic ectoderm into fully
differentiated neurons. Since then, her team has determined
that NeuroD plays a critical role in differentiation and survival
of pancreatic beta cells and a subset of neurons, including
granule cells of the hippocampus and cerebellum as well as
cochlear ganglia in the inner ear. Thus, mice lacking NeuroD
are diabetic, ataxic and deaf. Currently, members of her laboratory
are working to determine the molecular and cellular basis
of NeuroD-null phenotypse and the signaling pathways that
control NeuroD activity.
Selected Publications:
Lee, J.E., S. Hollenberg, L. Snider, D. Turner, N. Lipnick
and H. Weintraub (1995). Conversion of Xenopus ectoderm into
neurons by NeuroD, a new basic helix-loop-helix protein. Science
268:836-844.
Miyata, T., T. Maeda and J.E. Lee (1999). NeuroD is required
for differentiation of the granule cells in the cerebellum
and hippocampus. Genes & Dev. 13:1647-1652.
Kim, W.Y., Fritzsch, B., Serls, A., Bakel, L.A., Huang, E.
J., Reichardt, L.F., Barth, D.S., Lee, J.E. (2001). NeuroD-null
mice are deaf due to a severe loss of the inner ear sensory
neurons during development. Development 128: 417-426.
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