Henry Denison (1883–1911) was teaching in the Medical School when he died suddenly at age 28. His mother, Ella Strong Denison, donated the Boulder building as a memorial to her son.
Designed by J.B.B. Benedict (1879–1948), a flamboyant personality in Denver's architectural history, Denison is Benedict's only Boulder building.
Benedict designed some of Denver's grandest Beaux-Arts residences and churches. To allow for future expansion, the east side was left with a temporary exterior facing of red brick while the other three sides were finished with white brick and terra cotta trim.
Denison has housed offices for arts and sciences faculty for several years.