Clare 102 and Ramaley N222
Department of Integrative Physiology
University of Colorado
Boulder, CO 80309
Translational research - translating scientific discoveries into population health impact presents many unique challenges necessitating a multi-disciplinary approach that includes the study of genetic, physiological, behavioral, and environmental factors. As an epidemiologist and applied biostatistician, Professor McQueen's research objectives are focused on the development and application of epidemiological and biostatistical methods to advance our understanding of human disease from genes to populations. Toward that end, he has embraced highly integrative and collaborative research that approaches translational research in a comprehensive manner. Areas that broadly define his research include the epidemiology of behavior (HIV-risk behaviors, obesity), psychiatric disorders (substance use and dependence, conduct disorder, bipolar disorder, schizophrenia) and neurologic disorders (Alzheimer's disease, Parkinson's disease, multiple sclerosis).
- Director: Matthew B. McQueen, Sc.D.
- Post-doctoral Fellow: Jaime Derringer, Ph.D.
- Research Associates: Brett Haberstick, Ph.D.
- Graduate Students: Adam Bohr, M.S., Helena Yardley, M.S., Rakel Salamander, B.A.
- Undergraduate Students: TBA
- Collaborators: Robin Corley, Marissa Ehringer, Brett Haberstick, John Hewitt, Tom Johnson, Andy Smolen, Mike Stallings (Institute for Behavioral Genetics, University of Colorado Boulder); Roger Enoka, Moni Fleshner, Doug Seals, Chris DeSouza (Department of Integrative Physiology, University of Colorado Boulder); Ken Krauter (Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder); Rob Knight (Biofrontiers Institute, University of Colorado Boulder); Matt Keller, Theresa Hernandez, Soo Rhee (Department of Psychology, University of Colorado Boulder); Jason Boardman, Jane Menken (Department of Sociology, University of Colorado Boulder); Michael Allen, Tom Crowley, Christian Hopfer, Susan Mikulich-Gilbertson, Joe Sakai (Department of Psychiatry, University of Colorado Denver-Anschutz Medical Center); Scott Biggins (Department of Gastroenterology, University of Colorado Denver-Anschutz Medical Center); John Hokanson (Department of Epidemiology, Colorado School of Public Health) Jane Gralla (Department of Biostatistics, Colorado School of Public Health); Sara Yeatman (Department of Behavioral Sciences, University of Colorado Denver); Kathleen Harris (Carolina Population Center, University of North Carolina, Chapel Hill, NC); Goncalo Abecasis (Department of Biostatistics, University of Michigan); Steve Tollman, Kathleen Kahn (School of Public Health, University of the Witwatersrand, Johannesburg, South Africa); Alex Ezeh, Catherine Kyobutungi (African Population and Health Research Center, Nairobi, Kenya).
Current Research Projects
- Substance use and HIV risk behavior
- Genetics of substance use and abuse
- Gene-by-Environment (GxE) interactions and obesity
- Epidemiology of obesity
Opportunities for Undergraduates
The requirements for undergraduates who want a research experience in human epidemiology, including genetic approaches are:
- Either have completed or be currently enrolled in IPHY 2800 (Introductory Statistics)
- Have an interest in using epidemiological and statistical tools to study health outcomes
- Enroll in Independent Study (i.e. IPHY 4860) for 8-10 hours/week for at least one semester.
- 2009-2014, NIH/NIDA P60, "Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors", Core B: Data Management, Informatics and Biostatistics (Boulder PI: McQueen; Denver PI: Mikulich-Gilbertson).
- 2009-2014, NIH/NIDA P60, "Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors", Component 1: Genetics of Adolescent Antisocial Drug Dependence and HIV-Related Risk Factors (Boulder PI: McQueen; Denver PI: Hopfer).
- 2009-2014, NIH/NIAAA R01, "Translational Studies of Nicotinic Receptor Genes: Alcohol and Nicotine Behaviors" (PI: Ehringer).
- 2010-2015, NIH/NICHD R01, "Social Demographic Moderation of Genome-Wide Associations for Body Mass Index" (PI: McQueen, Boardman).
- 2010-2015, NIH/NIDA R01, "A Genetic Study of Personal Traits that Promote or Inhibit Individual Well-Being" (PI: Conger, Stallings).