Integrative Physiology of Aging Laboratory Phone: 303-492-2485 Fax: 303-492-6778

Research Initiatives

• Molecular mechanisms associated with cardiovascular aging. Oxidative stress is the exposure of the body's cells to molecules called reactive oxygen species that are generated continuously in the body as a function of normal metabolism. We will study how the function of blood vessels can be affected by reactive oxygen species and the expression of a number of proteins in your vessel wall. If you wish to volunteer contact Molly (303-492-2485; cvstudy@colorado.edu).


• Inflammatory Suppression of Endothelial Function with Aging and Habitual Exercise. We know that inflammation and oxidative stress are related to insulin resistance and endothelial function. This study examines if blocking inflammation improves vascular function and insulin resistance in subjects with varying characteristics. If interested please contact Molly (303-492-2485; cvstudy@colorado.edu).


• Role of PPARalpha in the Prevention of Vascular Aging. As we age, the function of our blood vessels decreases. One reason for this decline in function is increased inflammation and oxidative stress. This study examines a receptor (PPARalpha) found inside the cells of your blood vessel. The amount of this receptor decreases with age. Having more of this receptor reduces inflammation and oxidative stress. If interested, please contact Molly or Rachelle (303-492-7702; health.study@colorado.edu).


• The Role of Oxidative Stress and Inflammation on Arterial Function. Risk factors for cardiovascular disease (e.g. aging, high blood pressure, high cholesterol) are associated with decreases in the ability of your blood vessels to dilate (i.e., increase in size) in response to increases in blood flow through the vessel. The purpose of this study is to test the relation between oxidative stress and inflammation on your arteries to dilate in adult men and women. If you are interested in participating in this study contact Molly (303-492-2485; cvstudy@colorado.edu).


• A Low Sodium Diet and Vascular Function. This is an intervention study to examine how a low sodium diet may improve vascular function in older adults with moderately elevated blood pressure. While it is well established that a diet low in sodium can lower blood pressure, this study will explore other potential benefits that a low sodium diet may have on blood vessel function. If you are interested in participating in this study contact Keri (303-735-6410; IPAlab@colorado.edu).


• Habitual Aerobic Exercise, Inflammation, and Vascular Function. We know that habitual aerobic exercise improves vascular function in middle-aged and older adults. However, it is unclear how exercise has this effect. In this study, we will determine the role of reduced inflammation in the vascular improvements seen after 2-months of aerobic exercise (walking). If interested please contact Molly (303-492-2485; cvstudy@colorado.edu).


• Vitamin D Supplementation and Vascular Function. This is an intervention study to examine how vitamin D supplementation may improve vascular function in middle aged and older adults with vitamin D deficiency. The study will involve 12 weeks of taking vitamin D or placebo and measuring vascular function before and after this period. If you are interested in participating in this study contact Keri (303-735-6410; IPAlab@colorado.edu). Study still in review process; recruitment has not begun.

• Free medical screening and diagnostic testing (bone scans, exercise stress tests, ultrasound, blood tests) completed by professional medical personnel.
• Financial compensation for your participation.
• All studies have passed rigorous examination by the University Ethical Research Review Board and are supported by the National Institutes of Health.