Douglas R. Seals Douglas R. Seals, Ph.D. Department of Integrative Physiology University of Colorado Boulder, CO 80309 phone: 303-492-5305 fax: 303-492-6778 e-mail: seals@colorado.edu

Research Interests

• “Vascular aging”, particularly the changes in large artery stiffness and vascular endothelial function that occur with physiological and pathophysiological aging.


• Biological and lifestyle factors that influence vascular aging.


• The integrative (molecular to systemic) mechanisms that mediate vascular aging and its modulation by biological and lifestyle factors.


• Integrative Physiology of Aging Laboratory.

Education

• 1972-76, B.S./B.S., Education/Business Administration, William Jewell College, Liberty, MO.


• 1977-79, M.S., Applied/Exercise Physiology, University of Wisconsin, Madison, WI.


• 1979-81, Ph.D., Applied/Exercise Physiology, University of Wisconsin, Madison, WI.

Professional Experience

• 1981-1984, Postdoctoral Research Fellow, Department of Medicine, Section of Applied Physiology, Washington University School of Medicine, St Louis, MO.


• 1984-1985, Assistant Professor, Department of Exercise Science, University of Iowa, Iowa City, IA.


• 1985-1988, Assistant Professor, Department of Exercise and Sport Sciences, University of Arizona, Tucson, AZ.


• 1987-1989, Assistant Professor, Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ.


• 1989-1992, Associate Professor, Department of Exercise and Sport Sciences, University of Arizona, Tucson, AZ.


• 1990-1992, Associate Professor, Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ.


• 1992-1995, Associate Professor, Department of Kinesiology, University of Colorado, Boulder, CO.


• 1993-1995, Associate Professor, Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO.


• 1995-1998, Professor, Department of Kinesiology, University of Colorado, Boulder, CO.


• 1996-Present, Professor, Department of Medicine, Divisions of Cardiology and Geriatric Medicine, University of Colorado Health Sciences Center, Denver, CO.


• 1998-2002, Professor, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO.


• 2000-2004, Assistant Program Director, UC-Boulder General Clinical Research Center.


• 2003-Present, Professor, Department of Integrative Physiology, University of Colorado, Boulder, CO.


• 2008-Present, Arts and Sciences College Professor of Distinction, Department of Integrative Physiology, University of Colorado, Boulder, CO.

Honors and Awards

• 1988-1993, Research Career Development Award, National Institute on Aging.


• Fellow, American Heart Association Councils on Basic Cardiovascular Sciences, High Blood Pressure Research, and Nutrition, Physical Activity and Metabolism.


• 1999-2005, Editor-in-Chief, Exercise and Sport Sciences Reviews.


• 1999-present, Associate Editor, Journal of Applied Physiology


• 1999-2003, NIH IRG Member, Clinical Aging Review Committee, National Institute on Aging.


• 2003, Citation Award, American College of Sports Medicine.


• 2005, Herbert H. deVries Award for Distinguished Research in the Field of Aging.


• 2004-present, NIH, National Institute on Aging MERIT Award (R37 AG013038).


• 2006, UC-Boulder Faculty Assembly Award for Research, Scholarly, and Creative Work.


• 2008, College of Arts and Sciences Professor of Distinction

Recent Publications

• Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelial-dependent dilation and upregulation of nuclear factor KB. Circulation Research 100: 1659-1666, 2007.


• Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. Journal of Physiology 571: 661-668, 2006.


• Gates PE, Boucher ML, Silver AM, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine biovailability or endothelial asymmetric dimenthylarginine protein expression. Journal of Applied Physiology 102: 63-71, 2007.


• Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores leg blood flow in healthy older men. Journal of Applied Physiology 103: 1715-1721, 2007.


• Moreau KL, DePaulis AR, Gavin, KM, Seals DR. Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women. Journal of Applied Physiology 102: 890-895, 2007.


• Moreau KL, Silver AM, Dinenno FA, Seals DR. Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. European Journal of Cardiovascular Prevention and Rehabilitation 13: 805-811, 2006.


• Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FB, Donato AJ, Seals DR. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 51: 1-8, 2008.


• Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47phox expression and evidence of endothelial oxidative stress. Circulation 115: 627-637, 2007.