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Douglas R. Seals
Douglas R. Seals, Ph.D.
Department of Integrative Physiology
University of Colorado
Boulder, CO 80309
phone: 303-492-5305
fax: 303-492-6778
e-mail: seals@colorado.edu
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Research Interests
- Vascular aging, particularly the changes in large artery stiffness and vascular endothelial function that occur with physiological and pathophysiological aging.
- Biological and lifestyle factors that influence vascular aging.
- The integrative (molecular to systemic) mechanisms that mediate vascular aging and its modulation by biological and lifestyle factors.
- Integrative Physiology of Aging Laboratory.
Education
- 1972-76, B.S./B.S., Education/Business Administration,
William Jewell College,
Liberty, MO.
- 1977-79, M.S., Applied/Exercise Physiology, University
of Wisconsin, Madison, WI.
- 1979-81, Ph.D., Applied/Exercise
Physiology, University of Wisconsin, Madison, WI.
Professional Experience
- 1981-1984, Postdoctoral Research Fellow, Department of
Medicine, Section of Applied Physiology, Washington
University School of Medicine, St Louis, MO.
- 1984-1985, Assistant Professor, Department of Exercise
Science, University of Iowa,
Iowa City, IA.
- 1985-1988, Assistant Professor, Department of Exercise
and Sport Sciences, University
of Arizona, Tucson, AZ.
- 1987-1989, Assistant Professor, Department of Physiology,
University of Arizona Health Sciences Center, Tucson, AZ.
- 1989-1992, Associate Professor, Department of Exercise
and Sport Sciences, University of Arizona, Tucson, AZ.
- 1990-1992, Associate Professor, Department of Physiology,
University of Arizona Health Sciences Center, Tucson, AZ.
- 1992-1995, Associate Professor, Department of Kinesiology,
University of Colorado,
Boulder, CO.
- 1993-1995, Associate Professor, Department of Medicine,
Division of Cardiology, University
of Colorado Health Sciences Center, Denver, CO.
- 1995-1998, Professor, Department of Kinesiology, University of Colorado, Boulder, CO.
- 1996-Present, Professor, Department of Medicine, Divisions
of Cardiology and Geriatric Medicine, University of Colorado
Health Sciences Center, Denver, CO.
- 1998-2002, Professor, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO.
- 2000-2004, Assistant Program Director, UC-Boulder General
Clinical Research Center.
- 2003-Present, Professor, Department of Integrative Physiology,
University of Colorado, Boulder, CO.
- 2008-Present, Arts and Sciences College Professor of Distinction, Department of Integrative Physiology, University of Colorado, Boulder, CO.
Honors and Awards
- 1988-1993, Research Career Development Award, National Institute on Aging.
- Fellow, American Heart Association Councils on Basic Cardiovascular Sciences, High Blood Pressure Research, and Nutrition, Physical Activity and Metabolism.
- 1999-2005, Editor-in-Chief, Exercise and Sport Sciences Reviews.
- 1999-present, Associate Editor, Journal of Applied Physiology
- 1999-2003, NIH IRG Member, Clinical Aging Review Committee, National Institute on Aging.
- 2003, Citation Award, American College of Sports Medicine.
- 2005, Herbert H. deVries Award for Distinguished Research in the Field of Aging.
- 2004-present, NIH, National Institute on Aging MERIT Award (R37 AG013038).
- 2006, UC-Boulder Faculty Assembly Award for Research, Scholarly, and Creative Work.
- 2008, College of Arts and Sciences Professor of Distinction
Recent Publications
- Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelial-dependent dilation and upregulation of nuclear factor KB. Circulation Research 100: 1659-1666, 2007.
- Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. Journal of Physiology 571: 661-668, 2006.
- Gates PE, Boucher ML, Silver AM, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine biovailability or endothelial asymmetric dimenthylarginine protein expression. Journal of Applied Physiology 102: 63-71, 2007.
- Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores leg blood flow in healthy older men. Journal of Applied Physiology 103: 1715-1721, 2007.
- Moreau KL, DePaulis AR, Gavin, KM, Seals DR. Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women. Journal of Applied Physiology 102: 890-895, 2007.
- Moreau KL, Silver AM, Dinenno FA, Seals DR. Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. European Journal of Cardiovascular Prevention and Rehabilitation 13: 805-811, 2006.
- Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FB, Donato AJ, Seals DR. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 51: 1-8, 2008.
- Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47phox expression and evidence of endothelial oxidative stress. Circulation 115: 627-637, 2007.
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