Douglas R. Seals Douglas R. Seals, Ph.D. Department of Integrative Physiology University of Colorado Boulder, CO 80309 phone: 303-492-5305 fax: 303-492-6778 e-mail: seals@colorado.edu

Research Interests

• “Vascular aging”, particularly the changes in large artery stiffness and vascular endothelial function that occur with physiological and pathophysiological aging.


• Biological and lifestyle factors that influence vascular aging.


• The integrative (molecular to systemic) mechanisms that mediate vascular aging and its modulation by biological and lifestyle factors.


• Integrative Physiology of Aging Laboratory.

Education

• 1972-76, B.S./B.S., Education/Business Administration, William Jewell College, Liberty, MO.


• 1977-79, M.S., Applied/Exercise Physiology, University of Wisconsin, Madison, WI.


• 1979-81, Ph.D., Applied/Exercise Physiology, University of Wisconsin, Madison, WI.

Professional Experience

• 1981-1984, Postdoctoral Research Fellow, Department of Medicine, Section of Applied Physiology, Washington University School of Medicine, St Louis, MO.


• 1984-1985, Assistant Professor, Department of Exercise Science, University of Iowa, Iowa City, IA.


• 1985-1988, Assistant Professor, Department of Exercise and Sport Sciences, University of Arizona, Tucson, AZ.


• 1987-1989, Assistant Professor, Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ.


• 1989-1992, Associate Professor, Department of Exercise and Sport Sciences, University of Arizona, Tucson, AZ.


• 1990-1992, Associate Professor, Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ.


• 1992-1995, Associate Professor, Department of Kinesiology, University of Colorado, Boulder, CO.


• 1993-1995, Associate Professor, Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO.


• 1995-1998, Professor, Department of Kinesiology, University of Colorado, Boulder, CO.


• 1996-Present, Professor, Department of Medicine, Divisions of Cardiology and Geriatric Medicine, University of Colorado Health Sciences Center, Denver, CO.


• 1998-2002, Professor, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO.


• 2000-2004, Assistant Program Director, UC-Boulder General Clinical Research Center.


• 2003-Present, Professor, Department of Integrative Physiology, University of Colorado, Boulder, CO.


• 2008-Present, Arts and Sciences College Professor of Distinction, Department of Integrative Physiology, University of Colorado, Boulder, CO.

Honors and Awards

• 1988-1993, Research Career Development Award, National Institute on Aging.


• Fellow, American Heart Association Councils on Basic Cardiovascular Sciences, High Blood Pressure Research, and Nutrition, Physical Activity and Metabolism.


• 1999-2005, Editor-in-Chief, Exercise and Sport Sciences Reviews.


• 1999-present, Associate Editor, Journal of Applied Physiology


• 1999-2003, NIH IRG Member, Clinical Aging Review Committee, National Institute on Aging.


• 2003, Citation Award, American College of Sports Medicine.


• 2005, Herbert H. deVries Award for Distinguished Research in the Field of Aging.


• 2004-present, NIH, National Institute on Aging MERIT Award (R37 AG013038).


• 2006, UC-Boulder Faculty Assembly Award for Research, Scholarly, and Creative Work.


• 2008, College of Arts and Sciences Professor of Distinction


• 2008-present, NIH IRG Member, Aging Systems and Geriatrics Study Section.

Recent Publications

• Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NFkB, reduced IkBa and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 7:805-812, 2008.


• Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. Journal of Applied Physiology 105:1359-1363, 2008.


• Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski KL, Seals DR. Vascular endothelial dysfunction with aging: endothelin-I and endothelial nitric oxide synthase. American Journal of Physiology 297: H425-H432, 2009.


• Durrant JR, Seals DR, Connell ML, Russell MJ, Folian BJ, Donato AJ, Lesniewski LA. Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. Journal of Physiology 587: 3271-3285, 2009.


• Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Donato AJ, Seals DR. B6D2F1 mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. Journal of Gerontology: Biological Sciences 64A: 9-20, 2009.


• Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FB, Donato AJ, Seals DR. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 51: 1-8, 2008.


• Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR. Nuclear factor kB activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 119: 1284-1292, 2009.


• Seals DR, DeSouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. Journal of Applied Physiology 105: 1323-1332, 2008.


• Walker AE, Seals DR, Pierce GL, Gates PE, Eskurza I. Modulation of vascular endothelial function by low density lipoprotein cholesterol with aging: influence of habitual exercise. American Journal of Hypertension 22: 250-256, 2009.