David L. Allen David L. Allen, Ph.D. Department of Integrative Physiology University of Colorado Boulder, CO 80309-0354 phone: (303) 492-3175 fax: (303) 492-0811 e-mail: allendl@colorado.edu

Research Interests

• Transcriptional regulation of skeletal muscle gene expression.
• Molecular basis of skeletal muscle adaptation to exercise, disease, and aging.
Molecular mechanisms underlying exercise-induced muscle damage and repair.
• Molecular genetics of addiction.
• Molecular and Cellular Physiology Laboratory

Education

• 1985-1991, B.S., Department of Kinesiology, University of California, Los Angles, CA.
• 1991-1996, Ph.D., Department of Physiological Science, University of California, Los Angeles, CA.

Professional Experience

• 1996-1998, Postdoctoral Research Fellow, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI.
• 1998-2004, Research Associate, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO.
• 2004-present, Assistant Professor, Department of Integrative Physiology, University of Colorado, Boulder, CO.

Honors and Awards

• 1996-1998, University of Michigan Cardiovascular Center, NIH Postdoctoral Training Grant .
• 1998-2002, Muscular Dystrophy Association, Research Development Grant.
• 2000, Recipient of the Carl Gisolfi Travel Award for the Integrative Biology of Exercise Conference.
• 2004-2008, Mentored Research Scientist Development Award, National Institutes of Health
• 2005, Shih Chun Wang Young Investigator Award, American Physiological Society
• 2005, Research Endowment Award, American College of Sports Medicine
• 2007, American Physiological Society Research Career Enhancement Award Mentor for Dr. Min Du, University of Wyoming, $1500.00
• 2008, Travel award, NIH Workshop on The Establishment, Maintenance, and Turnover of Adipose Depots

Recent Publications

• Allen DL. Making sense (and antisense) of myosin heavy chain gene expression. Am J Physiol: Reg Int Physiol 2008.


• Allen DL, Cleary AS, Lindsay SF, Speaker KJ, Uyenishi J, Reed JM, Madden MC, Mehan RS. Myostatin, activin Receptor IIb, and follistatin-Like-3 gene expression is altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol: Metab and Endoc, 294: E918-E927, 2008.


• Allen D, Du M. Comparative functional analysis of the cow and mouse myostatin genes reveals novel regulatory elements in their upstream promoter regions. Comp Biochem Physiol 2008.


• Allen DL, Weber JN, Sycuro LK, Leinwand LA. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast myosin heavy chain transcription in vivo. Journal of Biological Chemistry 280: 17126-17134, 2005.


• Allen DL, Unterman TG. Regulation of myostatin expression and myoblast differentiation by SMAD and FoxO transcription factors. Am J Physiol Cell Physiol 292: C188-199, 2007.


• Beylkin DH, Allen DL, Leinwand LA. MyoD, Myf5 and the calcineurin pathway activate the developmental myosin heavy chain genes. Developmental Biology 294: 541-553, 2006.


• Bryan A, Hutchison KE, Seals DS, Allen DL. A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise. Health Psychology 26: 30-39, 2007.


• Hutchison KE, Allen DL, Jepson C, Lerman C, Benowitz N, Stitzel J, Bryan AB, McGeary J, Haughey HM. CHNA4 and tobacco dependence: from gene regulation to treatment outcome. Arch Gen Psychiatry 64: 1078-86, 2007.