Chemistry & Biochemistry
Cooperative Institute for Research in Environmental Sciences
The Environmental Program-University of Colorado Boulder
Secondary Core Area
Analytical chemistry, pharmaceutical science, aerosols, microparticles and nanoparticles, supercritical fluids, and thin film deposition.
Ph.D. 1960 University of Illinois
Director of CU-Boulder Environmental Program
Fundamental and applied studies of the formation of nanoparticle and microparticle aerosols are underway. Carbon dioxide-assisted nebulization provides superior aerosols for various forms of spectroscopy, such as electro-spray ionization, mass spectrometry and atomic absorption. Sievers' students are collaborating with pharmacists and physicians in the University of Colorado Health Sciences Center of Pharmaceutical Biotechnology, to develop new methods for delivery of aerosol particles useful in direct and painless administration of therapeutic drugs by inhalation. The drugs are dissolved or suspended in supercritical fluids, and unusually small aerosol particles are formed by rapid decompression to facilitate delivery of the aerosol particles to the most distal alveoli and to allow rapid uptake by the lungs. Formation of fine aerosols is expected to become increasingly important in the treatment or vaccination against influenza, infections, cystic fibrosis, asthma, and diabetes.
The simultaneous stabilization , drying, and micronization of vaccines, antibodies, proteins, antibiotics, and anti-inflammatory pharmaceuticals and other products of the biotechnology revolution are under study. Two of the fourteen “Grand Challenges” identified by the Gates Foundation and the NIH Foundation as critical to world health are being addressed by the Sievers group: needle-free administration of vaccines (by pulmonary or nasal aerosols), and vaccines that do not need refrigeration for long term storage.
Coatings of many materials can be deposited on complex surfaces and on particles from 70 nm to 30,00 nm by CAN-BD, a process patented by the Sievers group.