Kristi S. Anseth
Tisone Professor, Associate Professor of Surgery, Howard Hughes Medical Institute Investigator
ECCH 128
(303) 492-3147
kristi.anseth@colorado.edu
Curriculum Vitae
Anseth Research Group
Education:
B.S., Purdue University (1992)
Ph.D., University of Colorado (1994)
Awards:
•2011 - Distinguished Research Lecturer, CU-Boulder
•2010 - Dale Pearson Lectureship at UCSB
•2010 - Elected to the Institute of Medicine
•2009 - Professional Progress Award, American Institute of Chemical Engineers
•2009 - Elected to the National Academy of Engineering
•2009 - Materials Research Society, Fellow
•2008 - PopSci's 7th Annual Brilliant 10
•2008 - Named Distinguished Professor of the University of Colorado by CU Board of Regents
•2008 - Distinguished Engineering Alumni Award, University of Colorado
•2008 - Clemson Award for Basic Research from the Society for Biomaterials
•2007 - Dean’s Award for Outstanding Research in the College of Engineering & Applied Science
•2006 - American Association for the Advancement of Science, Fellow
•2005 - Elizabeth Gee Award, University of Colorado
•2004 - NSF Alan T. Waterman Award
•2003 - AIChE Allan P. Colburn Award
•2003 - ASEE McGraw Research Award
•2002 - Hutchinson Teaching Award, College of Engineering and Applied Science
•2001 - Materials Research Society Outstanding Young Investigator Award
•2001 - AIMBE Fellow
•2000 - Howard Hughes Medical Institute Assistant Investigator
Selected Publications:
•A.M. Kloxin, A.M. Kasko, C.N. Salinas and K.S. Anseth, “Photolabile hydrogels for dynamic tuning of physical and chemical properties,” Science, 324, 59-63 (2009)
•C.A. DeForest, B.D. Polizzotti and K.S. Anseth, “Sequential click reactions for synthesizing and patterning 3D cell microenvironments,” Nature Materials, 8,
659-64 (2009).
•C. Lin, A.T. Metters and K.S. Anseth, “Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFα,”
Biomaterials, 30, 4907-14 (2009).
•B.D. Fairbanks, M.P. Schwartz, A.E. Halevi, C.R. Nuttelman, C.N. Bowman and K.S. Anseth, “A versatile synthetic extracellular matrix mimic through thiol-ene
photopolymerization,” Advanced Materials, 21, 1-6 (2009).
•M.W. Tibbitt and K.S. Anseth, “Hydrogels as extracellular matrix mimics for 3D cell culture,” Biotechnology and Bioengineering, 103, 655-63 (2009).
•A.A. Aimetti, M.W. Tibbitt and K.S. Anseth, “Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels,” Biomacromolecules, 10, 1484-89 (2009).
•C.N. Salinas and K.S. Anseth, “Decorin moieties tethered into PEG networks induce chondrogenesis of human mesenchymal stem cells,” Journal of Biomedical Materials Research, 90A, 456-64 (2009).
•D.S.W. Benoit, M.J Schwartz, A.R. Durney and K.S. Anseth, “Small molecule functional groups for the controlled differentiation of human mesenchymal stem cells encapsulated in poly(ethylene glycol) hydrogels,” Nature Materials, 7,
816 - 823 (2008).
•B.D. Polizzotti, B.D. Fairbanks and K.S. Anseth, “Three-dimensional Biochemical Patterning of Click-based PEG Peptide Hydrogels,” Biomacromolecules, 9, 1084-7 (2008).
•H.S. Simms, C.N. Bowman and K.S. Anseth, “Using Living Radical Polymerization to Enable Facile Incorporation of Materials in Microfluidic Cell Culture Devices,” Biomaterials, 29, 2228-36 (2008).
•M.C. Cushing and K.S. Anseth, “Hydrogel Cell Cultures,” Science, 316, 1133-34 (2007)
Research Interests:
Biomaterials, Tissue Engineering, Photopolymerizations, and Degradable Polymer Networks
Many of the current biomaterials in clinical use today were originally developed for other applications, and such off-the-shelf materials became a biomaterial when someone pursued the trial-and-error process of implanting the material and "seeing what happens." In contrast to this approach, our group is pursuing new directions towards the rational design of biomaterials and, specifically, how photopolymerization processes can be used to provide numerous advantages for medical applications. For the past few years, we have been exploring, designing, and characterizing new generations of multifunctional macromers that can be photopolymerized to form degradable networks, where the degradation is predictable and readily controlled. From a biomaterial perspective, photoinitiated polymerizations are beneficial for many reasons including fast curing rates under physiological conditions, spatial and temporal control of the polymerization, and the ability to generate complex 3D structures in situ. The resulting degradable networks are advantageous since they circumvent the need for implant retrieval and are useful in applications ranging from controlled release of drugs to tissue engineering scaffolds. Currently, ongoing projects in our group include the design of new orthopaedic biomaterials for fracture fixation, photoencapsulation of chondrocytes for cartilage tissue engineering, biomimetic approaches to heart valve tissue engineering, microfluidic bioassays, photopolymerization of micro and nanoparticles for drug delivery, DNA delivery for tissue engineering applications, and photopolymerizable tissue adhesives. Our research combines a mixture of polymer chemistry and physics, molecular and cellular biology, and molecular simulations and modeling with fundamental engineering principles to address problems of importance to the fields of biomaterials and tissue engineering.
For details related to current research projects in our group, please visit www.Colorado.EDU/che/ansethgroup/.
