Results

BioServe Research Results

BioServe actively engages many types of organizations to conduct research in space. BioServe has been supporting space life science research since 1991. The list below summarizes research conducted by BioSeve and it's partners since August 2007.

Total Spaceflight Missions = 17
Total Spaceflight Experiments Supported = 42

Click on the plus sign [+] below right to expand and read about experimentation conducted on these missions:

HTV-3 7/21/2012 []


Experiment #1:  YouTube Space Lab - Bacillus subtilis

This investigation was proposed by two high school students from Troy Michigan as part of the YouTube Space Lab contest. YouTube Space Lab was world-wide contest which challenged 14-18 year old students to submit ideas for a biology or physics experiment that could be conducted on board the ISS. Two biology experiments were selected as the top global winners. The first experiment examined the anti-fungal properties of Bacillus subtilis (B. subtilis) in space. The students proposed that B. subtilis would react differently in space than the ground controls and that the space based cultures would have increased anti-fungal properties when compared to ground controls. Analysis of the space flight and ground controls is currently underway.
Hardware Utilized: 48 Fluid Processing Apparatus (FPAs) held within 6 Group Activation Packs (GAPs)
Type of Payload: Commercial, Educational
Sortie/ISS: ISS
Partners: YouTube, Space Adventures, NASA
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/YouTube_Space_Lab.html and http://www.nasa.gov/mission_pages/station/research/experiments/CBTM-3-Sclerostin_Antibody.html


Experiment #2: YouTube Space Lab – Predatory Behavior of the Jumping Spider in Space

The second top global winning experiment examined the predatory behavior of Jumping Spiders in space. The experiment was proposed by a student from Alexandria, Egypt. The student proposed that the Jumping Spider would not be able to adapt and catch its prey in space. The specific species flown were the Salticus scenicus or the zebra jumping spider and the Phiddipus johnsoni or red backed jumping spider along with a supply of fruit flies for food. Unlike orb weavers, the jumping spider does not spin a web to capture food. Jumping spiders are hunters. Once it visually identifies prey, it may stalk it for some distance prior to catching it. Once the jumping spider is within close proximity of its prey, it will secure a drag line using its silk and then jump with great speed onto the prey securing it with a lethal bite. This experiment sought to determine if the jumping spider altered its predation technique in a microgravity environment. Analysis of space flight and ground controls is currently underway.  
Hardware Utilized: 2 Spider Habitats, HS video imaging system and Commercial Generic Bioprocessing Apparatus (CGBA)
Type of Payload: Commercial, Educational
Sortie/ISS: ISS
Partner/s: YouTube, Space Adventures, NASA
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/YouTube_Space_Lab.html and http://www.youtube.com/spacelab

SpaceX CRS-1 10/07/2012 []


Experiment #1:  Genotypic and Phenotypic Responses of Candida albicans to Spaceflight (Micro-6)

Previous studies indicate that Candida albicans (C. albicans) respond to low-shear (low-stress) modeled microgravity (LSMMG) with gene expression changes and morphological (structural) consequences. Gene expression is the conversion of information from a gene to a functional product that the gives rise to structural and observable changes in the organism. The goal of this experiment was to further examine the responses of C. albicans to microgravity. It was hypothesized that exposure of C. albicans to microgravity would alter gene expression and morphology, consistent with a potential increase in virulence. This study endeavored to 1) inform the value of LSMMG for predicting the physiological responses of C. albicans, 2) further explore and document the phenotypic (observable characteristic) parameters of C. albicans that are associated with pathogenicity (ability to produce infectious disease) and altered during exposure to spaceflight, and 3) predict conserved responses of higher eukaryotes (cells with a nucleus), including humans, to space flight conditions.
Hardware Utilized: 128 Fluid Processing Apparatus (FPAs) within 16 Group Activation Packs (GAPs)
Type of Payload: Fundamental Science
Sortie/ISS: ISS
Partners: NASA Ames Research Center, University of Montana
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/Micro-6.html,
http://spacebiosciences.arc.nasa.gov/mission/micro-6,
http://spacebiosciences.arc.nasa.gov/story/micro-6-experiment-returns-iss,
http://www.montana.edu/cpa/news/nwview.php?article=11461

STS-135 7/08/2011 []


Experiment #1:  CBTM-03

This investigation assessed a sclerostin antibody as a novel bone forming agent for prevention of spaceflight-induced skeletal fragility in mice (CBTM-3-Sclerostin Antibody) is part of a suite of investigations studying the ability of novel experimental agents to prevent disuse induced bone loss, and extend current knowledge about the effects of microgravity on the musculoskeletal system and the ability of a ground-based analog system (rodent hind limb suspension) to reproduce those effects in mice. The ultimate objective is to mitigate the risk for space-induced skeletal fragility associated with missions to low Earth orbit, and exploration destinations.
Hardware Utilized: AEMs (NASA Ames)
Type of Payload: Commercial, Fundamental
Sortie/ISS: sortie
Partner/s: Amgen, UCB – Brussels, NASA Ames Research Center
Science Website: http://spacebiosciences.arc.nasa.gov/mission/cbtm-3-sts-135 and http://www.nasa.gov/mission_pages/station/research/experiments/CBTM-3-Sclerostin_Antibody.html and http://www.nasa.gov/mission_pages/station/research/experiments/CBTM-3-Vascular_Atrophy.html


Experiment #2: NLP-Vaccine 17

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html


Experiment #3: NLP-Cells 7

This experiment assessed the effects of microgravity on the formation, establishment and multiplication of undifferentiated cells and evaluated changes in cell structure, growth and development, genetic changes, and differential gene expression of Jatropha curcas, a biofuel plant. This study seeks to contribute to the development of new cultivars of this biofuel plant.
Hardware Utilized: petriGAPs
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc, University of Florida-Gainesville, Vecenergy Inc.
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells-Jatropha_Biofuels.html


Experiment #4: Micro 4

The goal of the Micro-4 experiment was to investigate how cells adapt to the unique aspects of the space environment, using the model eukaryotic organism, Saccharomyces cerevisiae.  Direct assessment of selective pressures on cell populations through generations has become possible due to the recent availability of the yeast deletion series. This powerful reagent consists of a collection of molecularly engineered isogenic yeast strains that differ only in a single gene locus (i.e. only one of a possible 6000 genes is deleted and each deleted gene has been replaced with a selectable marker and a unique identifying barcode. The deletions mutant can be grown under a selective pressure in an arrayed format on solid agar media in petri dishes and cell growth is assessed by measuring yeast colony size.
Hardware Utilized:
OPMs, CGBA
Type of Payload: Fundamental
Sortie/ISS:
ISS Partner/s: NASA Ames, Durham Veterans Affairs Medical Center, University of Toronto, University of Minnesota Science Website: http://spacebiosciences.arc.nasa.gov/mission/micro-4-sts-135 and http://www.nasa.gov/mission_pages/station/research/experiments/Micro-4.html


Experiment #5: Micro 2a

Micro-2A built on the results obtained from Micro-2 on STS-132, in the methods of cultivation of the organisms, the anti-microbial surfaces tested, and the mutant strains of the organisms used. The results from the STS-135 experiment not only complement the results obtained from STS-132 but also provide new data on the anti-biofilm action of additional surface coatings.
Hardware Utilized: GAPs, FPAs and CGBA
Type of Payload: Fundamental Science
Sortie/ISS: ISS
Partner/s: NASA Ames, Rensselaer Polytechnic Institute
Science Website: http://spacebiosciences.arc.nasa.gov/mission/micro-2a-sts-135 and http://www.nasa.gov/mission_pages/station/research/experiments/Micro-2A.html


STS-134 5/16/2011 []


Experiment #1: NLP-Vaccine 10

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine.html


Experiment #2-4:  CSI-05

This investigation examined the orb weaving characteristics of a Nephila clavipes (golden orb-web spiders), the movement behavior of fruit flies, and the thigmatropic (directional plant growth in response to a stimulus of direct contact) and phototropic (directional plant growth in response to a light source) responses that occur during seed germination in microgravity.
Hardware Utilized: Spider Habitat (SHAB), Plant Bracket and Flask, camera module system, CGBA
Type of Payload: Education and fundamental science
Sortie/ISS: ISS
Partner/s: Baylor College of Medicine Center for Educational Outreach, National Space Biomedical Research Institute, NASA ISS National Lab Education Office, Butterfly Pavilion, Denver Museum of Nature and Science, Orion’s Quest, NASA Ames Research Center
Science Website:
http://www.nasa.gov/mission_pages/station/research/experiments/CSI-05.html and http://www.bioedonline.org/space/STS_Mission_134S.cfm and http://www.bioedonline.org/space/STS_Mission_134P.cfm

STS-133 2/24/2011 []


Experiment #1: NLP-Vaccine 11

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella.
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-MRSA.html


Experiment #2: NLP-Cells 8

This experiment assessed the effects of microgravity on the formation, establishment and multiplication of undifferentiated cells and evaluated changes in cell structure, growth and development, genetic changes, and differential gene expression of Jatropha curcas, a biofuel plant. This study seeks to contribute to the development of new cultivars of this biofuel plant.
Hardware Utilized: petriGAPs
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc, University of Florida-Gainesville, Vecenergy Inc.
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells-Jatropha_Biofuels.html

STS-132 5/14/2010 []


Experiment #1:  NLP-Vaccine 9

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella
Hardware Utilized: GAPs and FPAs
Type of Payload:Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html


Experiment #2:  NLP-Cells 4

Jatropha Biofuels assessed the effects of microgravity on the formation, establishment and multiplication of undifferentiated cells and evaluated changes in cell structure, growth and development, genetic changes, and differential gene expression of Jatropha curcas, a biofuel plant. This study seeks to contribute to the development of new cultivars of this biofuel plant.
Hardware Utilized: GAPs and FPAs
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc, University of Florida-Gainesville, Vecenergy Inc.
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells-4.html


Experiment #3:  Micro 2

The investigation examined the gravitational effects on biofilm formation during space and how gravity alters biofilm (aggregation of microorganisms) formation with the goal of developing new strategies to reduce their impact on crew health and to minimize the harmful effects of biofilms on materials in space and on Earth.
Hardware Utilized: GAPs, FPAs and CGBA
Type of Payload: Fundamental Science
Sortie/ISS: ISS
Partner/s: NASA Ames, Rensselaer Polytechnic Institute Science Website:  http://biotech.rpi.edu/index.php/news/62-news/209-rensselaer-polytechnic-institute-researchers-send-bacteria-into-orbit-aboard-space-shuttle-atlantis

STS-133 4/5/2010 []


Experiment #1:  NLP-Vaccine 8

This investigation was part of a series of investigations designed to examine the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-MRSA.html


STS-130 2/8/2010 []


Experiment #1: NLP-Vaccine 7

This investigation examined Methicillin-resistant Staphylococcus aureus (NLP-Vaccine-MRSA) and used a unique and simple model of infection. The MRSA was grown in space under conditions known to effect bacterial potency. 
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sπortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical CenterScience Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html


Experiment #2:  NLP-Cells 3 Jatropha Biofuels

Jatropha Biofuels assessed the effects of microgravity on the formation, establishment and multiplication of undifferentiated cells and evaluated changes in cell structure, growth and development, genetic changes, and differential gene expression of Jatropha curcas, a biofuel plant. This study seeks to contribute to the development of new cultivars of this biofuel plant.
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc, University of Florida-Gainesville, Vecenergy Inc.
Science Website:  http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells-3.html


STS-129 11/16/2009 []


Experiment #1: NLP-Vaccine 6

This investigation examined Methicillin-resistant Staphylococcus aureus (NLP-Vaccine-MRSA) and used a unique and simple model of infection. The MRSA was grown in space under conditions known to effect bacterial potency, the strains which are identified as the least potent following microgravity exposure are selected as candidates for use in vaccine development on Earth. 
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s:
Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-MRSA.html


Experiment #2:  SPEGIS 2

This experiment investigated S. pneumoniae gene expression and protein production in the space environment. The identification of specific S. pneumoniae virulence factors and cellular and molecular processes may aid scientists in furthering the understanding of how this bacteria causes infection. This data may aid in the design and development of new antimicrobial drugs.
Hardware Utilized: FPAs, GAPs, and CGBA
Type of Payload: Fundamental
ScienceSortie/ISS: ISS
Partner/s: NASA Ames
Science Website: http://issresearchproject.nasa.gov/Ames/documents/SPEGIS%202%20STS-129.pdf


Experiment #3:  URC-Microbial 1

The experiment involved the study of morphological and molecular changes of Escheria coli and Bacillus subtilis microbes brought about by the space flight environment.
Hardware Utilized: FPAs, GAPs, and CGBA
Type of Payload: Educational, Proof of ConceptSortie/ISS:
ISSPartner/s: NASA Ames
Science Website: http://www.tsu.edu/pdffiles/academics/science/URC%20MICROBIAL%20-1%20FACT%20SHEET.pdf


Experiment #4:  CSI-03re Butterflies in Space

CSI-03re examined the complete life cycle of the Painted Lady butterfly and the Monarch butterfly.  Students compared how the complete life cycle of the butterfly differs in space, when compared to butterflies grown on Earth.
Type of Payload: Educational
Sortie/ISS: ISS
Partner/s: Baylor College of Medicine Center for Educational Outreach, National Space Biomedical Research Institute, Butterfly Pavilion, Monarch Watch
Science Website: http://www.bioedonline.org/space/STS_Mission_129.cfm and http://www.nasa.gov/mission_pages/station/research/experiments/CSI-03.html and http://www.nasa.gov/mission_pages/station/expeditions/expedition22/butterflies.html and http://monarchwatch.org/space/ and http://www.butterflies.org/UserFiles/File/Butterflies%20in%20Space%20Press%20Release%202009.pdf

STS-128 8/28/2009 []


Experiment #1: NLP-Vaccine 5

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity. The research focused on discovering information that would assist in the development of a vaccine to treat the illnesses caused by these microbes.
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html

STS-125 5/11/2009 []


Experiment #1: NLP-Vaccine 1C

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Streptococcus pneumoniae, Listeria monocytogenes, Entrococcus faecalis and Candida albicans.   The research focused on discovering information that would assist in the development of a vaccine to treat the illnesses caused by these microbes.
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/nlpv2.html


STS-119 3/15/2009 []


Experiment #1:  NLP-Vaccine 3

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Streptococcus pneumoniae, Listeria monocytogenes, Entrococcus faecalis and Candida albicans.   The research focused on discovering information that would assist in the development of a vaccine to treat the illnesses caused by these microbes.
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Survey.html

STS-126 11/14/2008 []


Experiment #1:  NLP-Vaccine 2

This investigation was part of a series of investigations designed to investigate the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment including MRSA and Salmonella
Hardware Utilized: GAPs and FPAs
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website:http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html


Experiment #2 NLP-Cells

This investigation examined the effects of microgravity on bovine hepatocytes (liver cells) and bile duct epithelium.
Hardware Utilized: OptiGAP and CGBA
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc. and USDA – Agricultural Research Services
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells.html


Experiment #3:  NLP-Cells

This investigation examined the effects of microgravity on cattle (bovine) zygotes (resulting from the union of a sperm and egg). Hardware Utilized: FPAs, GAPs and CGBA
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc. and USDA – Agricultural Research Services
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Cells.html


Experiment #4:  CSI-03 Butterflies in Space

This investigation examined the life cycle of the butterfly in microgravity compared to ground controls.Hardware Utilized:  Butterfly Habitat (BHAB), camera system module, and CGBA
Type of Payload: Educational
Sortie/ISS: ISS
Partner/s: Baylor College of Medicine Center for Educational Outreach, National Space Biomedical Research Institute, Butterfly Pavilion Westminster, CO, Denver Museum of Nature and Science, Orion’s Quest, Gulf Coast Butterflies
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-03.html


Experiment #5:  CSI-03 Spiders in Space

Examined the ability of orb weaving spiders to build orb webs in space and successfully catch food. Hardware Utilized:  Spider Habitat (SHAB), camera system module and CGBA
Type of Payload: Educational
Sortie/ISS: ISS
Partner/s: Baylor College of Medicine Center for Educational Outreach, National Space Biomedical Research Institute, Butterfly Pavilion, Denver Museum of Nature and Science, Orion’s Quest, Gulf Coast Butterflies, Mark Stowe
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-03.html

STS-124 5/31-6/14/2008 []


Experiment #1:  NLP-Vaccine 1B

This investigation was the second in a series of investigations designed to examine the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment.
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html

STS-123 3/11/2008 []


Experiment #1-4: Microbial Drug Resistance and Virulence (MDRV)

Microbial Drug Resistance and Virulence (MDRV) supported four independent investigators to determine the effect of space flight on the gene expression and virulence potential of four model microorganisms, Salmonella typhimurium, Streptococcus pneumoniae, Saccharomyces cerevisiae and Pseudomonas aeruginosa. These microorganisms were chosen because they are well studied organisms that have been, or have the potential to be, isolated from the Space Shuttle, Mir Space Station, International Space Station, or its crew, or have been shown to exhibit altered virulence in response to space flight. These organisms are all important human pathogens that cause a significant amount of human morbidity and mortality on Earth as well.
Hardware Utilized: GAPs, FPAs and CGBA
Type of Payload: Fundamental and Applied Science
Sortie/ISS: ISS
Partner/s: NASA HEOMD Barry Pyle, Ph.D., Montana State University, Bozeman, MT Cheryl A. Nickerson, Ph.D., Arizona State University, Tempe, AZ David W. Niesel, Ph.D., University of Texas Medical Branch, Galveston, Galveston, TX Michael McGinnis, Ph.D., University of Texas Medical Branch, Galveston, Galveston, TX
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/MDRV.html


Experiment #5:  NLP-Vaccine 1A

This investigation was the first in a series of investigations designed to examine the virulence (infection potential) of a variety of potentially harmful bacteria when grown in a microgravity environment. 
Type of Payload: Commercial
Sortie/ISS: sortie
Partner/s: Astrogenetix and Durham Veterans Affairs Medical Center
Science Website:  http://www.nasa.gov/mission_pages/station/research/experiments/NLP-Vaccine-Salmonella.html

STS-118 8/8/2007 []


Experiment #1: CBTM-02

Commercial Biomedical Test Module - 2 (CBTM-2) used a validated mouse model to examine the effectiveness of an experimental therapeutic as a possible countermeasure for muscle atrophy.
Hardware Utilized: AEMs (NASA Ames)
Type of Payload: Commercial Sortie/ISS: Sortie Primary Partner/s:  Amgen Inc., NASA Ames
Secondary Science Investigators and Respective Organizations: Secondi University of Napoli, Napoli, Italy
Allan Forsman, Ph.D., East Tennessee State University, Johnson City, TN, United States Brooke Harrison, Ph.D., University of Colorado, Boulder, Boulder, CO, United States Daila Gridley, Ph.D., Loma Linda University, Loma Linda, CA, United States David Allen, Ph.D., University of Colorado, Boulder, Boulder, CO, United States David Lacey, M.D., Amgen Research, Thousand Oaks, CA, United States Gregory A. Nelson, Ph.D., Loma Linda University, Loma Linda, CA, United States Jean-Luc Morel, Physiologie Cellulaire et Pharmacologie Moleculaire, Bordeaux, France Lora Green, Ph.D., Loma Linda University, Loma Linda, CA, United States Louis Stodieck, Ph.D., University of Colorado, BioServe Space Technologies, Boulder, CO, United States Michael Pecaut, Ph.D., Loma Linda University, Loma Linda, CA, United States Paolo Di Nardo, University of Rome Tor Vergata, Rome,Italy Stephen Keith Chapes, Ph.D., Kansas State University, Manhattan, KS, United States Ted A. Bateman, Ph.D., University of North Carolina, Chapel Hill, NC, United States Timothy G. Hammond, M.B.B.S., Durham Veterans Affairs Medical Center, Durham, NC, United States Virginia Ferguson, Ph.D., BioServe Space Technologies, University of Colorado, Boulder, CO, United States
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CBTM-2.html


Experiment #2: CSI-02 – Plant response to microgravity

Seeds of miniature tomato plants developed at North Carolina State University were germinated on orbit. Students and scientists sought to examine both root and stem growth via near real-time imaging.
Hardware utilized: Plant Habitat, camera module system, CGBA
Type of Payload: Fundamental Research and K-12 Education
Sortie/ISS: ISS
Partner/s: North Carolina State University – Adventures of the Agronauts
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-02.html


Experiment #3: CSI-02 – Chemical Garden

The experiment examined the growth mechanisms of crystalline fibers of metallic salts grown in a silicate solution.  Results can be found here http://www.ncbi.nlm.nih.gov/pubmed/21391639.
Hardware Utilized: Silicate Garden Habitat (SGHab), camera module system and CGBA
Type of Payload:
Fundamental Research and K-12 Education
Sortie/ISS: IS
Partner/s: University of Granada, Spain (science) and Orion’s Quest (education
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-02.html


Experiment #4:  CSI-02 – Yeast

The yeast experiment examined how cells adapt to the unique aspects of the space environment using the model eukaryotic organism, Saccharomyces cerevisiae. The experiment was directly designed to examine risks to the biological integrity and life-based support systems for long-term occupation of space.
Hardware Utilized: Cell Culture Habitat (CCHAB), camera module system, CGBA
Type of Payload: Fundamental Research and K-12 Education
Sortie/ISS: ISS
Partner/s: Tulane University
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-02.html


Experiment #5:  Plant Cell Culture

The principal objective of Cell Culture experiment is to evaluate whether cells of a monocotyledonous and a dicotyledonous plant could develop normally from the transitional stage into normal somatic embryos under space (microgravity) conditions. 
Hardware Utilized: CCHAB, camera module system, CGBA
Type of Payload: Commercial
Sortie/ISS: ISS
Partner/s: Zero Gravity Inc. 
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/CSI-02.html

Soyuz 10/10/2007 []


Experiment #1: Cells in Space

This study was designed to study the effects of microgravity on in vitro inflammation and endothelial dysfunction and gene expression of inflammatory and endothelial dysfunction markers in endothelial cells.
Hardware Utilized: FPAs
Type of Payload: Fundamental
Sortie/ISS: ISS
Partners: National Space Agency of Malaysia


Experiment #2: Microbes in Space

The design of the experiment was to study A. baumannii and E. cloacae treated with high concentration of imipenem and cefipime/imipenem respectively, in a microgravity environment and use genomic and proteomic tools to establish the gene expression and protein profiles and mass spectrometry to identify the specific protein profiles that were expressed.
Hardware Utilized: FPAs
Type of Payload: Fundamental
Sortie/ISS: ISS
Partners:
National Space Agency of Malaysia
Science website: http://www.nasa.gov/mission_pages/station/research/experiments/MIS.html


Experiment #3: Protein Crystals in Space

This experiment examined the crystal growth behavior of lipases on earth with those grown in microgravity and tested conditions that would potentially improve the protein crystallization process on earth as well in space.
Hardware Utilized: HDPCG (University of Alabama Hardware)
Type of Payload: Fundamental
Sortie/ISS: ISS Partners: National Space Agency of Malaysia
Science Website: http://www.energia.ru/eng/iss/researches/space-bio-38.html


Experiment #4: Top in Space

This educational physics investigation demonstrated spinning top motions in microgravity.
Hardware Utilized: BioServe machined top
Type of Payload: Educational
Sortie/ISS: ISS Partners: National Space Agency of Malaysia
Science Website: http://www.nasa.gov/mission_pages/station/research/experiments/Top.html