25. “Development of Agents That Modulate Protein-Protein Interactions in Membranes”, Zhao, T. X.; Martinko, A. J.; Le, V. H.; Zhao, J.; Yin, H.; Curr. Pharm. Des. 2009, in press.

24. “Evidence that Opioids May Have Toll Like Receptor 4 and MD-2 Effects”, Hutchinson, M. R.; Zhang, Y.; Shridhar, M.; Evans, J. H.; Buchanan, M. M.; Zhao, T. X.; Slivka, P. F.; Coats, B. D.; Rezvani, N.; Wieseler, J.; Hughes, T. S.; Landgraf, K. E.; Chan, S.; Fong, S.; Phipps, S.; Falke, J. J.; Leinwand, L. A.; Maier, S. F.; Yin, H.; Rice, K. C.; Watkins, L. R.; Brain Behav. Immun. 2009, 23, Article in Press. [Link]

23. “A Peptide Antagonist of the TLR4/MD2 Interaction”, Slivka, P. F.; Shridhar, M.; Lee, G. I.; Sammond, D. W.; Hutchinson, M. R.; Martinko, A. J.; Buchanan, M. M.; Sholar, P. W.; Kearney, J. J. Harrison, J. A.; Watkins, L. R.; Yin, H.; ChemBioChem 2009, 10, 645-649. [Link]

22. “Using Two Fluorescent Probes to Dissect the Binding, Insertion, and Dimerization Kinetics of a Model Membrane Peptide”, Tang, J.; Yin, H.; Qiu, J.; Tucker, M. J.; DeGrado, W. F;. Gai, F.; J. Am. Chem. Soc. 2009, 131, 3816-3817. [Link]

21. "Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein-Protein Interactions" in Protein Engineering (Köehrer, C.; RajBhandary, U. L. Ed.), Slusky, J. S; Yin, H.; DeGrado, W. F.; Springer Verlag, Nucl. Acids and Mol. Biol. 2009, 22, 315-338. [Link]

20. “Design, Synthesis, and Evaluation of Biotinylated Opioid Derivatives as Novel Probes to Study Opioid Pharamcology”, Li, Y.; Chase, A. R.; Slivka, P. F.; Baggett, C. T.; Zhao, T. X.; Yin, H.; Bioconjug. Chem. 2008, 19,2585-2589. [Link]

19. “Peptide Probes for Protein Transmembrane Domains”, Slivka, P. F.; Wong, J.; Caputo, G. A.; Yin, H.; ACS Chem. Biol. 2008, 3, 402-411.[Link][Introducing the Authors]

18. “Computationally Designed Peptide Inhibitors of Protein-Protein Interactions in Membranes”, Caputo, G. A.; Litvinov, R. I.; Li, W.; Bennett, J. S.; DeGrado, W. F.; Yin, H.; Biochemistry 2008, 47, 8600-8606. [Link]

17. “Exogenous Agents that Target Transmembrane Domains of Proteins”, Yin, H.; Angew. Chem. Int. Edit. 2008, 47, 2744-2752. [Cover Article][Link]

16. “Computational Design of Peptides that Target Transmembrane Helices”, Yin, H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo, G. A.; Bennett, J. S.; DeGrado, W. F.; Science 2007, 315, 1817-1822. [Full Text] [C&E News][Faculty of 1000]

15. “The Leech Product Saratin is a Potent Inhibitor of Platelet Integrin Alpha₂Beta₁ and von Willebrand Factor Binding to Collagen”, White, T. C.; Berny, M. A.; Robinson, D. K.; Yin, H.; DeGrado, W. F.; Hanson, S. R.; McCarty, O. J. T.; FEBS J. 2007, 274, 1481-1491. [Link]

14. “Protein Secondary Structure Mimetics as Modulators of Protein-Protein and Protein-Ligand Interactions” in Chemical Biology: From Small Molecules to System Biology and Drug Design (Schreiber, S. L.; Kapoor, T. M.; Wess, G. Ed.), Yin, H.; Hamilton, A. D.; Wiley-VCH Verlag GmbH & Co. KGaA (Weinheim), 2007, 1, Chapter 4.3. [Link][PDF]

13. “Alpha-Helix Mimetics in Drug Discovery” in Drug Discovery Research: New Frontiers in the Post-Genomic Era (Huang, Z. W. Ed.), Yin, H.; Lee, G. I.; Hamilton, A. D.; John Wiley & Sons (New York), 2007, Chapter 11: 281-299. [Link][PDF]

12. “Activation of Platelet Alpha_IIbBeta₃ by Exogenous Peptides Corresponding to the Transmembrane Domains of Alpha_IIb”, Yin, H.; Litvinov, R. I.; Vilaire, G.; Zhu, H.; Li, W.; Caputo, G. A.; Moore, D. T.; Lear, J. D.; Weisel, J. W.; DeGrado, W. F.; Bennett, J. S.; J. Biol. Chem. 2006, 281, 36732-36741. [Link]

11. “Arylamide-Based Antagonists that Disrupt the Integrin Alpha₂Beta₁-Collagen Interaction”, Yin, H.; Gerlach, L. O.; Miller, M. W.; Moore, D. T.; Liu, D. H.; Vilaire, G.; Bennett, J. S.; DeGrado, W. F.; Bioorg. Med. Chem. Lett. 2006, 16, 3380-3382. [Link]

10. “Arylamide Derivatives as Peptidomimetic Inhibitors of Calmodulin”, Yin, H.; Frederick, K. K.; Liu, D. H.; Wand, A. J.; DeGrado, W. F.; Org. Lett. 2006, 8, 223-225. [Link]

9. “Terphenyl-Based Alpha-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-x_L”, Yin, H.; Lee, G. I.; Sedey, K. A.; Kutzki, O.; Park, H. S.; Orner, B. P.; Ernst, J. T.; Wang, H. G.; Sebti, S. M.; Hamilton, A. D.; J. Am. Chem. Soc. 2005, 127, 10191-10196. [Link] [Faculty of 1000]

8. “Strategies of Targeting Protein-Protein Interactions Using Synthetic Agents”, Yin, H.; Hamilton, A. D.; Angew. Chem. Int. Edit. 2005, 44, 4130-4163. [Link][PDF]

7. “Terphenyl Derivatives as Alpha-Helical Mimetics of P53”, Yin, H.; Lee, G. I.; Park, H. Y.; Rodriguez, J. M.; Payne, G. J.; Sebti, S. M.; Hamilton, A. D.; Angew. Chem. Int. Edit. 2005, 44, 2704-2707. [Link][PDF]

6. “Terephthalamide Derivatives as Mimetics of Helical Peptides: Disruption of the Bcl-x_L/Bak Interaction”, Yin, H.; Lee, G. I.; Sedey, K. A.; Rodriguez, J. M.; Wang, H. M.; Sebti, S. M.; Hamilton, A. D.; J. Am. Chem. Soc. 2005, 127, 5463-5468. [Link]

5. “p53 Alpha-Helix Mimetics Antagonize P53/MDM2 Interaction and Activate P53”, Chen, L. H.; Yin, H.; Farooqi, B.; Sebti, S. M.; Hamilton, A. D.; Chen, J. D.; Mol. Cancer Ther. 2005, 4, 1019-1025. [Link]

4. “Terephthalamide Derivatives as Mimetics of the Helical Region of Bak Peptide Target Bcl-x_L Protein”, Yin, H.; Hamilton, A. D.; Bioorg. Med. Chem. Lett. 2004, 14, 1375-1379. [Link]

3. “Geranylgeranyltransferase I Inhibitor, GGTI-2154, Induces Breast Carcinoma Apoptosis and Tumor Regression in H-Ras Transgenic Mice”, Sun, J.; Ohkanda, J.; Coppola, D.; Yin, H.; Kothare, M.; Busiglio, B.; Hamilton, A. D.; Sebti, S. M.; Cancer Res. 2003, 63, 8922-8929. [Link]

2. “Design and Application of an Alpha-Helix-Mimetic Scaffold Based on an Oligoamide-Foldamer Strategy: Antagonism of the Bak BH3/ Bcl-x_L Complex”, Ernst, J.T.; Becerril, J.; Park, H. S.; Yin, H.; Hamilton, A. D.; Angew. Chem. Int. Edit. 2003, 42, 535-539. [Link][Faculty of 1000][PDF]      

1. “Development of a Potent Bcl-x_L Antagonist Based on Alpha-Helix Mimicry”, Kutzki, O.; Park, H. S.; Ernst, J. T.; Orner, B. P.; Yin, H.; Hamilton, A. D.; J. Am. Chem. Soc. 2002, 124, 11838-11839. [Link][Faculty of 1000]