Recent Publications

Taylor, DJ; Podell, EA; Taatjes, DJ; Cech, TR. Multiple POT1-TPP1 proteins coat and compact long telomeric ssDNA. J Mol Biol. 2011, 410: 10-17.

Bernecky, C; Grob, P; Ebmeier, CC; Nogales, E; Taatjes, DJ. Molecular architecture of the human Mediator–RNA polymerase II–TFIIF assembly. PLoS Biol. 2011, 9: e1000603.

Knuesel, MT; Taatjes, DJ. Mediator and post-recruitment regulation of RNA polymerase II. Transcription 2011, 2: 28-31.

Kagey, MH; Newman, JJ; Bilodeau, S; Zhan, Y; Orlando, DA; van Berkum, NL; Ebmeier, CC; Goossens, J; Rahl, PB; Levine, SS; Taatjes, DJ; Dekker, J; Young, RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010, 467: 430-435.

De Carlo, S; Lin, S; Taatjes, DJ; Hoenger, A. Molecular basis of transcription initiation in archaea. Transcription 2010, 1: 103-111.

Ebmeier, CC; Taatjes, DJ. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci. USA. 2010, 107: 11283-11288.

Meyer, KD; Lin, S; Bernecky, C; Gao, Y; Taatjes, DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol. 2010, 17: 753-760.

Taatjes, DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci. 2010, 35: 315-322.

Donner, AJ; Ebmeier, CC; Taatjes, DJ; Espinosa, JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010, 17: 194-201.

Knuesel, MT; Meyer, KD; Bernecky, C; Taatjes, DJ. The human CDK8 subcomplex is a molecular switch that controls Mediator co-activator function.  Genes & Dev. 2009, 23: 439-451.

Knuesel, MT; Meyer, KD; Donner, AJ; Espinosa JM; Taatjes, DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of Mediator. Mol Cell Biol. 2009, 29: 650-661.

Panning, B; Taatjes, DJ. Transcriptional Regulation: It takes a Village. Mol Cell 2008, 31: 622-629.

Meyer, KD; Donner, AJ; Knuesel, MT; York, AG; Espinosa, JM; Taatjes, DJ. Cooperative activity of CDK8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 2008, 27: 1447-1457.

All Publications

Taatjes, DJ; Gaudiano, G; Resing, K; Koch, TH. Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J. Med. Chem. 1996, 39: 4135-4138.

Taatjes, DJ; Gaudiano, G; Resing, K; Koch, TH. A redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs, Adriamycin and Daunomycin.  J. Med. Chem. 1997, 40: 1276-1286.

Fenick, DJ; Taatjes, DJ; Koch, TH. Doxoform and Daunoform: anthrcycline-formaldehyde conjugates toxic to resistant tumor cells. J. Med. Chem. 1997, 40: 2452-2461.

Taatjes, DJ; Gaudiano, G; Koch, TH. Production of formaldehyde and DNA-adriamycin or –daunomycin adducts, initiated through redox chemistry of DTT/iron, xanthine oxidase/NADH/iron, or glutathione/iron. Chem. Res. Toxicol. 1997, 10: 953-961.

Taatjes, DJ; Fenick, DJ; Gaudiano, G; Koch, TH. A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer.  Curr. Pharm. Des. 1998, 4: 217-232.

Taatjes, DJ; Fenick, DJ; Koch, TH. Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate, toxic to resistant tumor cells.  J. Med. Chem. 1998, 41: 1306-1314.

Taatjes, DJ; Koch, TH. Growth inhibition, nuclear uptake, and retention of anthracycline-formaldehyde conjugates in prostate cancer cells relative to clinical anthracyclines.  Anticancer Res. 1999, 19: 1201-1208.

Podell, E; Harrington, D; Taatjes, DJ; Koch, TH. Crystal structure of Epidoxorubicin-formaldehyde virtual crosslink to DNA and evidence of its formation in human breast cancer cells. Acta Cryst. 1999, D55: 1516-1523.

Taatjes, DJ; Fenick, DJ; Koch, TH. Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines. Chem. Res. Toxicol. 1999, 12: 588-596. [Cover]

Kato, S; Burke, PJ; Fenick, DJ; Taatjes, DJ; Bierbaum, VM; Koch, TH. Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. Chem. Res. Toxicol. 2000, 13: 509-516.

Taatjes, DJ; Koch, TH. Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells. Curr. Med. Chem. 2001, 8: 15-29.

Dernell, WS; Powers, BE; Taatjes, DJ; Cogan, P; Gaudiano, G; Koch, TH. Evaluation of the epidoxorubicin-formaldehyde conjugate, Epidoxoform, in a mouse mammary carcinoma model. Cancer Invest. 2002, 20: 712-723.

Taatjes, DJ; Näär, AM; Andel, F; Nogales, E; Tjian, R. Structure, function, and activator-induced conformations of the CRSP coactivator. Science 2002, 295: 1058-1062.

Näär, AM;Taatjes, DJ; Zhai, W; Tjian, R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 2002, 16: 1339-1344.

Taatjes, DJ; Marr, MT; Tjian, R. Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol. 2004, 5: 403-410.

Taatjes, DJ; Schneider-Poetsch, T; Tjian, R. Distinct conformational states of nuclear receptor-bound CRSP–Med complexes. Nat Struct Mol Biol. 2004, 11: 664-671.

Taatjes, DJ; Tjian, R. Structure and function of CRSP/Med2: a promoter-selective transcriptional coactivator complex. Mol Cell. 2004, 14: 675-683.

Meyer, KD; Donner, AJ; Knuesel, MT; York, AG; Espinosa, JM; Taatjes, DJ. Cooperative activity of CDK8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 2008, 27: 1447-1457.

Panning, B; Taatjes, DJ. Transcriptional Regulation: It takes a Village. Mol Cell 2008, 31: 622-629.

Knuesel, MT; Meyer, KD; Donner, AJ; Espinosa JM; Taatjes, DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of Mediator. Mol Cell Biol. 2009, 29: 650-661.

Knuesel, MT; Meyer, KD; Bernecky, C; Taatjes, DJ. The human CDK8 subcomplex is a molecular switch that controls Mediator co-activator function.  Genes & Dev. 2009, 23: 439-451.

Donner, AJ; Ebmeier, CC; Taatjes, DJ; Espinosa, JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010, 17: 194-201.

Taatjes, DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci. 2010, 35: 315-322

Meyer, KD; Lin, S; Bernecky, C; Gao, Y; Taatjes, DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol. 2010, 17: 753-760.

Ebmeier, CC; Taatjes, DJ. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci. USA. 2010, 107: 11283-11288.

DeCarlo, S; Lin, S; Taatjes, DJ; Hoenger, A. Molecular basis of transcription initiation in archaea. Transcription 2010, 1: 103-111.

Kagey, MH; Newman, JJ; Bilodeau, S; Zhan, Y; Orlando, DA; van Berkum, NL; Ebmeier, CC; Goossens, J; Rahl, PB; Levine, SS; Taatjes, DJ; Dekker, J; Young, RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010, 467: 430-435.

Knuesel, MT; Taatjes, DJ. Mediator and post-recruitment regulation of RNA polymerase II. Transcription 2011, 2: 28-31.

Bernecky, C; Grob, P; Ebmeier, CC; Nogales, E; Taatjes, DJ. Molecular architecture of the human Mediator–RNA polymerase II–TFIIF assembly. PLoS Biol. 2011, 9: e1000603.

Taylor, DJ; Podell, EA; Taatjes, DJ; Cech, TR. Multiple POT1-TPP1 proteins coat and compact long telomeric ssDNA. J Mol Biol. 2011, 410: 10-17.

Patents

“New anthracycline anti-tumor drugs with enhanced cytotoxicity: compounds, compositions, and methods,” Dylan J. Taatjes, David J. Fenick, Tad H. Koch Inventors, US Patent No. 6,677,309.