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Andrew J. PHILLIPS
Office Phone: 303 735 2049
E-mail: Andrew.Phillips@colorado.edu
FAX: 303 492 5894
Lab: Cristol Chemistry 265
Lab Phone: 303
Group Website: http://spot.colorado.edu/~aphillip/
Ph.D.: University of Canterbury (New Zealand), 1999
Postdoctoral Fellow: University of Pittsburgh, 1999-2001
Synthetic Organic Chemistry and Total Synthesis
My research interests are broadly framed by natural products synthesis. Historically, natural products have played a significant role in the development of organic chemistry, particularly in the areas of synthesis, biosynthesis, theory, and spectroscopy. Although many believe organic synthesis has entered a ‘mature phase’, the total synthesis of a natural product remains one of the most broad and rewarding educational experiences for aspiring organic chemists, as well as providing a vehicle for the discovery and exploration of new reactivity and theory. Against this setting, projects in my research group focus primarily on two aspects of organic synthesis: a) the development of new chemical reactions and b) the total synthesis of complex natural products.
A significant contemporary issue in organic synthesis is the question of efficiency. Many synthetic methods leave much to be desired regarding efficiency, reliability and predictability. Our program in methodology development is designed to provide new or improved methods that can be applied to both the synthesis of natural products as well as other classes of interesting molecules.
We are also pursuing the total synthesis of a number of marine natural products. Compounds are chosen because of the opportunities they afford to demonstrate novel synthetic strategies and methodology as well as potent biological activity [particularly anti-cancer activity].
Selected Publications
Highly Selective Asymmetric Acetate Aldol Reactions of an N-Acetyl Thiazoldinethione Reagent. Zhang, Y.; Phillips, A. J.; Sammakia, T. Org. Lett. 2003, 5, ASAP.
"Ring-opening–ring-closing metathesis of bicyclo[2.2.2]octenes: a novel synthesis of decalins and hydrindanes". Minger, T. L.; Phillips, A. J. Tetrahedron Lett., 2002, 43, 5357.
"‘Practical and Highly Selective Oxazolidinethione-Based Asymmetric Acetate Aldol Reactions with Aliphatic Aldehydes". Guz, N. R.; Phillips, A. J. Org. Lett., 2002, 4, 2253.
"Bis(2-propanolato)[(1,2-)-1-propene]titanium". Phillips, A. J. in 'The Electronic Encyclopedia of Reagents for Organic Synthesis'. Paquette, L. A. Ed. Wiley, NY, 2002.
"Di-μ-chlorodichlorobis(η2-ethene)diplatinum". Phillips, A. J. in 'The Electronic Encyclopedia of Reagents for Organic Synthesis'. Paquette, L. A. Ed. Wiley, NY, 2002.
"‘Dichloro[(1,2,3,4,5,6-)-1-methyl-4-(1-methylethyl)benzene](tricyclohexyl phosphine) ruthenium". Phillips, A. J. in 'The Electronic Encyclopedia of Reagents for Organic Synthesis'. Paquette, L. A. Ed. Wiley, NY, 2001.
"Dichloro(3,3-diphenyl-2-propenylidene)bis(tricyclohexylphosphine)ruthenium". Phillips, A. J. in 'The Electronic Encyclopedia of Reagents for Organic Synthesis'. Paquette, L. A. Ed. Wiley, NY, 2001.
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