Department of

Research Interests of Faculty Participating in the Biochemistry Graduate Program

DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY

Natalie Ahn, Ph.D. Signal transduction and protein phosphorylation; functional proteomics and mass spectrometry.

Robert Batey, Ph.D. X-ray crystallography of ribonucleoprotein enzymes and complexes.

Marvin Caruthers, Ph.D. Nucleic acid chemistry and biochemistry, regulation and control of gene expression

Thomas Cech, Ph.D. RNA catalysis and splicing; RNA structure including X-ray crystallography; chromosome telomeres and telomerase.

Garry Dahlmann, Ph.D. Small-molecule screens, DNA replication mechanisms.

Bruce Eaton, Ph.D. SELEX, RNA and DNA catalysis, inorganic nanoparticle synthesis by RNA.

John H Evans , Ph.D. C2 and PH Domins and Their Host Proteins; Ca2+ and Phosphoinositide Signaling in Inate Immunity

Joseph Falke, Ph.D. Molecular studies of receptors, kinases and signaling proteins, structural and mechanistic studies of receptors and membrane-associated signaling proteins.

Ray Fall, Ph.D. Environmental biochemistry, mechanisms plants and microorganisms use to produce volatile organic compounds

James Goodrich, Ph.D. Eukaryotic transcriptional regulation, regulatory RNAs, gene expression in T cells, enzymology

Ralph Jimenez, Ph.D. Protein dynamics, biomolecular motions, ultrafast laser spectroscopy

Rob Knight, Ph.D. Bioinformatics, RNA evolution, evolution of pathogenicity islands, nucleotide substitution patterns, biological networks

Tad Koch, Ph.D. Design, synthesis, and evaluation of drugs targeted to breast and prostate cancer, especially metastatic resistant cancer.

Robert Kuchta, Ph.D. Enzyme mechanisms and inhibition in DNA replication.

Jennifer Kugel, Ph.D. Regulation of transcription by RNA polymerase, mechanism of RNA polymerase II transcription.

Xuedong Liu, Ph.D. TGF beta signal transduction mechanisms in normal and cancer cells; ubiquitin mediated proteolysis and cell cycle control.

Charles McHenry, Ph.D. Enzymology of DNA replication, structure and mechanisms of polymerases, HIV.

David Nesbitt, Ph.D. Confocal spectroscopy of single molecules, scanning tunneling (STM) microscopies for laser imaging of nanostructures and biomolecules.

Amy Palmer, Ph.D. Chemical biology, biosensor design, imaging of signal transduction pathways.

Arthur Pardi, Ph.D. RNA structure and function; catalytic RNA; protein-RNA recognition; NMR and single molecule structure methodology.

Andrew Phillips, Ph.D. Synthetic organic chemistry, total synthesis, natural products.

Kathy Rowlen, Ph.D. Bioanalytical chemistry, spectroscopy, and nanotechnology; Development of a diagnostic microarray for influenza.

Katheryn Resing, Ph.D. Development of high-throughput methods for proteomics data collection and bioinformatics analyses.

Tarek Sammakia, Ph.D. Synthetic methods, total synthesis of natural products, asymmetric reactions.

Marcelo Sousa, Ph.D. Structural biology of macromolecular complexes.

Dylan Taatjes, Ph.D. Study of large complexes that regulate gene expression; electron microscropy.

Alexey Wolfson, Ph.D. The mechanism and specificity of RNA-protein interactions.

Deborah Wuttke, Ph.D. Structural biology and biochemistry of telomeres, picornavirus, and the estrogen receptor.

Hubert Yin, Ph.D. Drug Discovery, identifying potential therapeutics that inhibit opioids-induced glial cell activation, protein engineering for targeting membrane receptors.

DEPARTMENT OF MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY

Tom Blumenthal, Ph.D. Mechanisms of pre-mRNA processing: splicing and 3' end formation; logic of gene organization on C. elegans chromosomes: eukaryotic operons.

Robert Boswell, Ph.D. Molecular genetics of Drosophila oogenesis and early embryogenesis.

Shelley Copley, Ph.D. Molecular evolution; enzyme mechanisms; biodegradation of environmental pollutants; antibiotic resistance.

Brian DeDecker, Ph.D. How cell fates are determined by the regulation of the Notch developmental pathway. Drug development for autoimmune diseases by targeting class II MHC.

Corrella Detweiler, Ph.D. How pathogenic bacteria evade and manipulate mammalian immune systems. Molecular mechanisms of Typhoid fever.

Mark Dubin Ph.D. Cognitive neurosciences.

Joaquin Espinosa, Ph.D. Mechanisms of transcriptional regulation by the tumor suppressor p53.

Larry Gold, Ph.D. SELEX/aptamers.

Nancy Guild, Ph.D. Transcriptional and post transcriptional regulation of gene expression in bacteriophage T4.

Min Han, Ph.D. Molecular genetics of differentiation and migration during nematode development.

Andy Hoenger, Ph.D. Structural and functional investigations into cytoskeletal assemblies by cryo electron microscopy and 3D image analysis.

Kevin Jones, Ph.D. Development and plasticity of neural circuitry. Molecular genetics of mouse neural development.

Michael Klymkowsky, Ph.D. Cell adhesion, cytoskeletal organization and gene expression.

Kenneth Krauter, Ph.D. The genetics of complex human traits and genome organization.

Leslie Leinwand, Ph.D. Genetic manipulation of cardiac and skeletal muscle development and function in mice; gene therapy; cardiac genetic disease.

Jens Lykke-Andersen, Ph.D. mRNA processing, translation and turnover in mammalian cells.

Jennifer Martin, Ph.D. Tumor virology; human B-cell immortalization by Epstein-Barr virus.

J. Richard McIntosh, Ph.D. Biophysical cytology; 3-D structure of cells; mechanism of mitosis.

Greg Odorizzi, Ph.D. Genetics and cell biology; membrane trafficking and phosphoinositide signaling in eukaryotic cells.

Bradley Olwin, Ph.D. Signalling in skeletal muscle development and regeneration; isolation and characterization of muscle stem cells.

Norman Pace, Ph.D. Ribozyme biochemistry; molecular ecology of microbial ecosystems.

Thomas Perkins, Ph.D. Single molecule studies of molecular motors.

Robert Poyton, Ph.D. Regulation of gene expression in yeast; oxidative stress: bioenergetics; mitochondrial dysfunction and aging.

Ravinder Singh, Ph.D. RNA-protein interactions, bioinformatics and molecular-genetic analysis of splicing regulation and sex determination.

L. Andrew Staehelin, Ph.D. Cell structure and trafficking; cryo-microscopy and electron tomography.

Gretchen Stein, Ph.D. Aging and resistance to oxidative stress in mammalian cells; toxicity of beta-amyloid peptide in neuronal cells.

Michael Stowell, Ph.D. Structure and mechanism at the chemical synapse; ion channels; endocytosis, synaptic architecture and plasticity.

Tin Tin Su, Ph.D. Cell cycle regulation in Drosophila.

Jonathan Van Blerkom, Ph.D. Regulation oogenesis and early mammalian embryogenesis.

Gia Voeltz, Ph.D. Organelle biogenesis: the regulation of organelle structure and shape by membrane proteins.

Mark Winey, Ph.D. Centrosome duplication in yeast and vertebrate cells, and basal body duplication in Tetrahymena.

William B. Wood, Ph.D. Genetic control and molecular biology of embryonic development in the nematode C. elegans.

Ding Xue, Ph.D. Mechanisms of programmed cell dealth in the nematode C. elegans and in mammals.

Michael Yarus, Ph.D. RNA in translation; catalytic RNA; RNA structure and function, the RNA world.

DEPARTMENT OF CHEMICAL AND BIOLOGICAL ENGINEERING

Kristi Anseth, Ph.D. Biomaterials, photopolymerization, tissue engineering, and drug delivery.

Christopher Bowman, Ph.D. Biomaterials, photopolymerization, reaction kinetics, polymer chemistry.

Stephanie Bryant, Ph.D. Functional tissue engineering, photopolymerization, biomaterials.

Robert Davis, Ph.D. Fluid mechanics of suspensions, sedimentation, coagulation, particle collisions in fluids, microbial suspensions, biotechnology.

Ryan Gill, Ph.D. Evolutionary and inverse metabolic engineering, genomics.

Melissa Mahoney, Ph.D. Novel drug delivery and tissue engineering strategies to promote regeneration in the central nervous system.

DEPARTMENT OF APPLIED MATHEMATICS

David Bortz, Ph.D. Mathematical modeling of biofilms and pathogens.

Manuel Lladser, Ph.D. Probability, automata, pattern matching in RNA sequences.

DEPARTMENT OF COMPUTER SCIENCE

Debra Goldberg, Ph.D. Combinatorial algorithms; graph theory; computational molecular biology; genomic network analysis; analysis of noisy and error-prone data.

DEPARTMENT OF PHYSICS

Meredith Betterton, Ph.D. Mathematical modeling of complex biological systems.

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Department of Chemistry and Biochemistry · University of Colorado, Boulder