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Biopharmaceuticals

Microstructure of spray-lyophilized samples for stabilized, inhalable protein therapeutics.

Rat pulmonary macrophage engulfing microparticles containing  anti-tuberculosis drugs.

Visualization of flow in the eye used for computation of distribution patterns for drug release intravitreally from biodegradable microparticles.

Faculty: Gill, Kompala, Randolph, Stansbury

Biopharmaceuticals research in the department includes development of efficient production schemes, novel delivery technologies and stable formulations for new drugs composed of proteins, peptides, RNA and DNA. Applications include:

• Room-temperature-stable vaccine formulations
• Genetic engineering to maximize protein folding in vivo
• High pressure technologies for refolding proteins
• Mechanistic understanding of the effects of processes such as lyophilization or microencapsulation on protein aggregation kinetics
• Studies of mechanisms for development of drug resistance in pathogenic bacteria