Ph.D. Projects

PhD Projects Academic Year 2013-14

Last Name

First Name

Advisor

Project Title

Becka

Eftalda

Bowman

Photoinitiated thiol-Vinyl Sulfones Networks as Dental Composites and Novel Biomaterials

Brown

Tobin

Anseth

Dynamic Cell Scaffolds through Photochemical Reactions. 

Chin

Huai-Ying (Heidi)

Schwartz

Single-Molecule biomaterials and Nanomaterials Research

Chu

Stanley

Bryant

Personalizing Matrix Assisted Autologous Chondrocyte Implantation. 

Chubukov

Boris

Weimer/Clough

Model of a Moving Bed Carbothermal Reduction Reactor to produce MG metal 

Dischinger

Sarah

Gin/Noble

Development of nanoporous liquid crystal polymer membranes for water purification and fermentation process separations

Domenech Corts

Anna

Gill

Ongoing project with the Gill Group – Did not go through the project selection process.

Dong

Miao Li (Milly)

Randolph

Nanoparticle Adjuvants in Vaccine Formulation Design

Ehrhart

Brian

Weimer

Ongoing project with the Weimer Group – Did not go through the project selection process.

Ellis

Lucas

Medlin/Schwartz

Control of surface reactivity through manipulation of the near-surface environment

Escalas Bordoy

Antoni

Chatterjee

Understanding antimicrobial resistance and developing new approaches for discovery of “next-generation smart antimicrobials”. 

Hao

Pengxiao

Medlin/Schwartz

Control of surface reactivity through manipulation of the near-surface environment

Kellogg

Kevin

Hrenya

Agglomeration and Entrainment of Cohesive Particles

Konetski

Danielle (Dani)

Bowman

Synthetic Bioorthorgonal Membrane Formation Using "Photo-Click" Technology

Kuo

Yu-Ching

Musgrave/Hynes

Collaboration project between Chemical and Biological Engineering and Chemistry

Marozas

Ian

Anseth

Dynamic Cell Scaffolds through Photochemical Reactions. 

Mendez

Daniel

In Progress

Namikis

Rudolfs (Rudy)

In Progress

Otoupal

Peter

Chatterjee

Engineered synthetic genetic devices for bioenergy and gene therapy applications

Rowe

Scott

Clough/Weimer

Advanced Process Control System for a Hybrid Solar reactor control system

Singh

Zoban

Gin/Noble

Ionic liquid-based membranes for highly selective Co2/Ch4 Separation

Song

Han Byul

Bowman

Photomediated CuAAC reaction and it's application in dental fillings and other material research applications

Sorret

Lea

Randolph

Aggregation in Formulations of Therapeutic Proteins

Weltz

James

Kaar/Schwartz

Single-molecule characterization of protein structure, function, and dynamics on material surfaces

Yaghoubi Rad

Ima

Stansbury

Ongoing project with the Stansbury Group – Did not go through the project selection process.

Yin

Xun (Chauncy)

Schwartz

Single-Molecule biomaterials and Nanomaterials Research

PhD Projects Academic Year 2012-13

Graduate Student Advisor Project Title Project Description
Elizabeth Aisenbrey Stephanie Bryant Engineering the osteochondral interface: Optimizing the differentiation of hMSCs in multi-layered biomimetic hydrogel for chondrogenesis Millions of people suffer from severe pain and joint immobility due to osteoarthritis. Osteoarthritis is a degenerative joint disease which causes damage to the cartilage and bone tissue of the osteochondral interface. The regeneration of the ostechondral tissue interface is complex, yet critical to the function of the joint. The focus of my research is to develop a multi-layered biomimetic hydrogel with spatially controlled biochemical moieties and biomechanical cues to optimize the differentiation of human mesenchymal stem cells (hMSCs) for the cartilaginous layers of the osteochondral interface.
Aaron Aziz Stephanie Bryant Ostechondral Interfacial Tissue Engineering: Optimization of osteogenesis within a Multi-Layered Hydrogel Osteoarthritis (OA) is a degenerative joint disease that drastically affects patient mobility and decreases the quality of life for millions of people around the world. Tissue engineering the osteochondral interface, which aims to regenerate cartilage and underlying bone (both of which are affected by OA), offers hope of repairing damaged joints in an OA-afflicted aging population in ways that are not currently possible. By spatially controlling the local mechanical properties and biochemical factors within a bioinert poly(ethylene glycol) hydrogel, and determining optimal mechanical loading regimes using novel bioreactors, I hope to optimize osteogenic differentiation of human mesenchymal stem cells for the bony tissue layers of the osteochondral interface.
Josep Casamada Ribot Prashant Nagpal / Anushree Chatterjee Plasmonic biosensing In vivo and in vitro sensing of biomolecules using plasmonic devices.
Nuria Codina Castillo Joel Kaar Bioactive sutures for preventing fibrosis in injured skeletal muscle tissue The aim of this project is the development of bioactive sutures for preventing fibrosis in injured skeletal muscle tissue. It consists in the immobilization of the enzyme matrix metalloproteinase-1 (MMP-1), that catalyzes the degradation of extracellular matrix proteins including collagen, on polyethylene terephthalate (PET) fibers. In order to do that we will incorporate non-natural amino acids in MMP-1 that will react with PET fibers
Colleen Courtney Anushree Chatterjee The Design of Smart Antimicrobials The design of smart antimicrobials using antisense RNA will be investigated both computationally and experimentally.
Keesha Erickson Anushree Chatterjee / Ryan Gill Investigating mutational-space of metabolic networks for optimizing pathways for biofuel production The project entails the creation of mathematical models that facilitate the engineering of metabolic networks by providing a means to connect genetic mutations to final system response, with the ultimate goal of utilizing the model to select mutations that optimize microbial biofuel production. The model will be refined and validated through genome-scale experiments.
Kirsten Fitch Andrew Goodwin Design of a Mechanically-Sensitive Polymer Network as a Platform for Novel Drug Delivery Systems and High-Performance Materials This project aims to develop a polymer network that can be degraded by mechanical strain or thermal activation. Following evaluation and optimization of the material properties, the material will be incorporated into drug-carrying microbubbles that can be mechanically activated by ultrasound, leading to drug release.
Samuel Goodman Jennifer Cha / Prashant Nagpal DNA Conjugated Semiconductor Nanoparticles for Thin Film Devices This project consists of studying the effects of DNA on the self-assembly of nanoparticle films and characterizing the electronic properties of these materials.
Daniel Johnson Arthi Jayaraman Molecular Simulations of Polycation-Polyanion binding for drug and gene delivery This study will begin by focusing on the properties of complexes formed between generic polyelectrolytes in order to facilitate the use of polycations as a carrier for gene and drug delivery.
Ke Ma Jennifer Cha Nanoscale bio-sensors for protein detection

Research is focused on amplifying optical responses for protein detection from virus scaffolds and generating enhanced spectroscopic signals from nanoparticle based sensors through protein binding.

Matthew McBride Chris Bowman Shape memory "click" polymers I will be employing  "click" chemistry, specifically the copper (I) catalyzed reaction between an azide and alkyne, to develop shape memory polymers with tunable properties.
Joseph Plaks Joel Kaar Protein Engineering for Enhanced Biocastalyst Function This project entails the chemical and genetic modification of enzymes to allow for catalysis in expanded and unnatural contexts
Chen Wang Chris Bowman Photoinitiated "Click" reaction photocatalysis, photopolymerization and photomodificaton via the Cu(I) Catalyzed Azide-Alkyne Reaction.