research

Chelsea Kirschner publishes "Hydrogels in Healthcare: From Static to Dynamic Microenvironments" in Acta Materialia

January 23, 2013

Chelsea Kirschner publishes a nice review of dynamic hydrogel environments titled "Hydrogels in Healthcare: From Static to Dynamic Microenvironments" in Acta Materialia. She summarized current progress in light, enxyme, electric field, temperature, and pH sensitive hydrogels for biomedical applications.

Malar Azagarsamy publishes "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds" in ACS Macro Letters

December 17, 2012

Malar Azagarsamy wrote an fantastic review of bioorthogonal click chemistry covering thiol-ene, click, and Michael addtions.

M.A Azagarsamy and K.S. Anseth, "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds," ACS Macro Letters, 2, 5-9 (2013)

Kelly Schultz publishes "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle Tracking Microrheology" in Soft Matter

December 17, 2012

Kelly Schultz showed that thiol-ene step-growth hydrogels degrade homogeneously when exposed to enzymes.

K.M. Schultz and K.S. Anseth, "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle Tracking Microrheology," Soft Matter (2012).

Chun Yang publishes "Cell-Mediated Delivery of Glucocorticoids from Thiol-Ene Hydrogels" in Journal of Controlled Release

December 17, 2012

Chun Yang showed controlled release of Dexamethasone led to osteogenic differentiation of human mesenchymal stem cells.

C. Yang, P.D. Mariner, J.N. Nahreini, and K.S. Anseth, "Cell-Mediated Delivery of Glutocorticoids from Thiol-Ene Hydrogels," Journal of Controlled Release, 162, 612-618 (2012).

Mark Tibbitt publishes "Dynamic Microenvironments: The Fourth Dimension" in Science Translational Medicine

November 16, 2012

Mark just published a perspicacious perspective on 4D cellular microenvironments in Science Translational Medicine. Reprint is available here.

M.W. Tibbitt and K.S. Anseth, "Dynamic Microenvironments: The Fourth Dimension," Science Translational Medicine, 4, 160ps24 (2012).

Nava Gandavarapu publishes "Extracellular Matrix Protein Adsorption to Phosphate-Functionalized Gels from Serum Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells" in Acta Biomaterialia

November 6, 2012

Nava showed that the osteogenic differentiation of hMSCs in hydrogels functionalized with phosphate groups can be attributed to serum protein adsorption.

April Kloxin and Katie Lewis publish "Responsive Culture Platform to Examine the Influence of Microenvironmental Geometry on Cell Function in 3D" in Integrative Biology

November 6, 2012

April, now an assistant professor at University of Delaware, and Katie presented a dynamic culture platform in which microwells are patterned and later connected through cytocompatible photocleavage of a poly(ethylene glycol)-based hydrogel to examine matrix geometry effects on cell fate.

Chelsea Kirschner publishes "In Situ Control of Cell Substrate Microtopographies Using Photolabile Hydrogels" in Small

November 6, 2012

Chelsea demonstrated that human Mesenchymal Stem Cells align along topographies patterned on the surface of photodegradable hydrogels. She further showed that cells will dynamically change their cytoskeletal organization in response to a modified topography.

Cole DeForest publishes "Bioactive Hydrogels for Regenerative Medicine" in Annual Review of Chemical and Biomolecular Engineering

October 18, 2012

Former group member Cole DeForest, now performing postdoctoral research under David Tirrell, published an excellent review of cutting edge bioactive hydrogel reserach titled "Bioactive Hydrogels for Regenerative Medicine" in Annual Review of Chemical and Biomolecular Engineering.

Abby Bernard publishes "A Microwell Culture Platform for the Aggregation of Pancreatic Beta-Cells" in Tissue Engineering Part C-Methods

September 4, 2012

Abby Bernard showed that pancreatic beta-cells aggregates could be formed in photopolymerized microwell devices. These cell aggregates secreted significantly more insulin per cell than dispersed cells.

A.B. Bernard, C.C. Lin, and K.S. Anseth, "A Microwell Culture Platform for the Aggregation of Pancreatic Beta-Cells," Tissue Engineering Part C-Methods, 18 (8), 583-592 (2012).

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