research

Danny Alge publishes "Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry" in Biomacromolecules

March 15, 2013

Danny Alge showed hydrogels could be formed using the bioorthogonal tetrazine-norbornene reaction. The synthetic accessibility of these chemistries will open new doors for the design of cell instructive materials.

D.A. Alge, M.A. Azagarsamy, D.F. Donohue, and K.S. Anseth, "Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry," Biomacromolecules (2013).

Mark Tibbitt publishes "Modeling Controlled Photodegradation in Optically Thick Hydrogels" in Journal of Polymer Science Part A: Polymer Chemistry

March 15, 2013

Mark Tibbitt demonstrates differences in photodegradation between step- and chain-growth hydrogels based on fundamental polymer physics theory.

M.W. Tibbitt, A.M. Kloxin, and K.S. Anseth, "Modeling Controlled Photodegradation in Optically Thick Hydrogels," Journal of Polymer Science Part A: Polymer Chemistry (2013).

Kyle Kyburz publishes "Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density" in Acta Biomaterialia

February 25, 2013

Kyle Kyburz demonstrated the importance of adhesive ligand interactions and network crosslinking density on hMSC migration and spreading.

K.A. Kyburz and K.S. Anseth, "Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density," Acta Biomaterialia (2013).

Daniel McKinnon publishes "Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons" in Biomaterials Science

January 28, 2013

Daniel McKinnon demonstrated the 3D culture of motor neurons in engineered PEG hydrogels that enabled good viability and robust axon extention. He further demonstrated the importance of ECM-mimic peptides to the viability of dissociated cells and the role of hydrogel modulus and crosslinker in axon extension.

Chelsea Kirschner publishes "Hydrogels in Healthcare: From Static to Dynamic Microenvironments" in Acta Materialia

January 23, 2013

Chelsea Kirschner publishes a nice review of dynamic hydrogel environments titled "Hydrogels in Healthcare: From Static to Dynamic Microenvironments" in Acta Materialia. She summarized current progress in light, enxyme, electric field, temperature, and pH sensitive hydrogels for biomedical applications.

Malar Azagarsamy publishes "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds" in ACS Macro Letters

December 17, 2012

Malar Azagarsamy wrote an fantastic review of bioorthogonal click chemistry covering thiol-ene, click, and Michael addtions.

M.A Azagarsamy and K.S. Anseth, "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds," ACS Macro Letters, 2, 5-9 (2013)

Kelly Schultz publishes "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle Tracking Microrheology" in Soft Matter

December 17, 2012

Kelly Schultz showed that thiol-ene step-growth hydrogels degrade homogeneously when exposed to enzymes.

K.M. Schultz and K.S. Anseth, "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle Tracking Microrheology," Soft Matter (2012).

Chun Yang publishes "Cell-Mediated Delivery of Glucocorticoids from Thiol-Ene Hydrogels" in Journal of Controlled Release

December 17, 2012

Chun Yang showed controlled release of Dexamethasone led to osteogenic differentiation of human mesenchymal stem cells.

C. Yang, P.D. Mariner, J.N. Nahreini, and K.S. Anseth, "Cell-Mediated Delivery of Glutocorticoids from Thiol-Ene Hydrogels," Journal of Controlled Release, 162, 612-618 (2012).

Mark Tibbitt publishes "Dynamic Microenvironments: The Fourth Dimension" in Science Translational Medicine

November 16, 2012

Mark just published a perspicacious perspective on 4D cellular microenvironments in Science Translational Medicine. Reprint is available here.

M.W. Tibbitt and K.S. Anseth, "Dynamic Microenvironments: The Fourth Dimension," Science Translational Medicine, 4, 160ps24 (2012).

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