April 24, 2014
Samir Singh showed scaffold modulus and peptide functionalization affected tumor cell migration in a 3D synthetic matrix. His paper, entitled "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" appears in Biomaterials Science.
March 31, 2014
Daniel McKinnon and Dylan Domaille (postdoc in Jen Cha's lab) "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials.
March 17, 2014
Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials. She shows that hMSCs differentiate differently when exposed to surfaces of different moduli for different periods of time. Congratulations Chun!
February 26, 2014
Emi Tokuda and Jen Leight published "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials showing the synergistic effect of matrix mechanics and melonoma drugs on cell response.
E.Y. Tokuda, J.L. Leight, and K.S. Anseth, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness," Biomaterials (2014).
February 17, 2014
Nava showed the ability to reversibly exchange biochemical ligands using allyl sulfide-based living click strategies. Congratulations Nava!
N.R. Gandavarapu, M.A. Azagarsamy, and K.S. Anseth, "Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands," Advanced Materials (2014).
February 10, 2014
Chelsea Kirschner showed the ability to use microtopographies to dynamically modulate valvular interstitial cell fate. Congratulations Chelsea!
C.M. Kirschner, D.L. Alge, S.T. Gould, and K.S. Anseth, "Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype," Advanced Healthcare Materials (2014).
January 28, 2014
Sarah Gould's paper entitled "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation" demonstrates the essence of the interplay between VICs and VECs in maintaining a healthy valve phenotype. She further investigates the role of nitric oxide as a paracrine signaling molecule using a L-NAME, a soluble NO analog.