research

Navakanth Gandavarapu publishes "Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity" in Biomaterials Science

November 18, 2013

Nava showed that a5b1 integrin binding can induce osteogenic differentiation of hMSCs on stiff but not soft substrates. Congratulations Nava!

N.R. Gandavarapu, D.L. Alge and K.S. Anseth, "Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity," Biomaterials Science (2013).

Sharon (Huan) Wang publishes "Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway" in PNAS

November 12, 2013

Sharon Wang showed valvular interstitial cells respons to matrix elasticity through the PI3K/AKT pathway in her new paper entitled "Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway" in PNAS. Congratulations Sharon!

http://www.pnas.org/content/early/2013/11/07/1306369110.abstract

Malar Azagarsamy publishes "Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins" in Angewandte Chemie

November 7, 2013

Malar Azagarsamy publishes "Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins" in Angewandte Chemie showing orthogonal photo-release of two different proteins using two wavelengths of light. Congratulations Malar!

Daniel McKinnon publishes "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems" in Advanced Materials

October 14, 2013

Daniel McKinnon publishes "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems" in Advanced Materials. He developed a cytocompatible covalently adaptable hydrogel that enabled cell spreading and fusion and will allow future studies on the role of matrix biophysical properties on cell function.

Danny Alge publishes "Facile and efficient Lewis acid catalyzed synthesis of an asymmetric tetrazine useful for bio-orthogonal click chemistry applications" in Tetrahedron Letters

August 14, 2013

Danny Alge and his undergraduate researcher Dylan Donohue characterized the addition of a lewis acid catalyst (nickel) in the synthesis of a tetrazine molecule useful in click chemistry applications.

Sharon (Huan) Wang publishes "Characterization of Cell Subpopulations Expressing Progenitor Cell Markers in Porcine Cardiac Valves" in PLoS ONE

July 28, 2013

Sharon Wang showed the unique gene expression profiles of several valvular interstitial subtypes. Her work will have deep impact in the heart disease community and showed that a certain subpopulation of cells participates in tissue repair and regeneration.

Jen Leight publishes "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate" in Biomaterials

July 8, 2013

Jen Leight showed spatially resolved cellularly MMP activity through a FRET reporter peptide. She showed increased MMP expression in response to TGF-beta and higher substrate modulus. This is an excellent follow-up to her June Employee of the Month Award! Congratulations Jen!

Sarah Gould publishes "Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease" in Circulation Research

July 8, 2013

Sarah Gould published a rad review of the role of matrix elasticity in aortic cell disease in Circulation Research. Congratulations Sarah!

S.T. Gould, S. Srigunapalan, C.A. Simmons, and K.S. Anseth, "Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease," Circulation Research (2013).

Katie Lewis publishes "Hydrogel Scaffolds to Study Cell Biology in Four Dimensions" in MRS Bulletin

March 15, 2013

Katie described the advantages of photolabile hydrogel platforms in an MRS Bulletin celebrating Kristi's mid-career award.

K.J.R. Lewis and K.S. Anseth, "Hydrogel Scaffolds to Study Cell Biology in Four Dimensions," MRS Bulletin, 38 (3), 260-268 (2013).

Danny Alge publishes "Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry" in Biomacromolecules

March 15, 2013

Danny Alge showed hydrogels could be formed using the bioorthogonal tetrazine-norbornene reaction. The synthetic accessibility of these chemistries will open new doors for the design of cell instructive materials.

D.A. Alge, M.A. Azagarsamy, D.F. Donohue, and K.S. Anseth, "Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry," Biomacromolecules (2013).

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