January 28, 2014
Sarah Gould's paper entitled "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation" demonstrates the essence of the interplay between VICs and VECs in maintaining a healthy valve phenotype. She further investigates the role of nitric oxide as a paracrine signaling molecule using a L-NAME, a soluble NO analog.
November 18, 2013
Nava showed that a5b1 integrin binding can induce osteogenic differentiation of hMSCs on stiff but not soft substrates. Congratulations Nava!
N.R. Gandavarapu, D.L. Alge and K.S. Anseth, "Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity," Biomaterials Science (2013).
November 12, 2013
Sharon Wang showed valvular interstitial cells respons to matrix elasticity through the PI3K/AKT pathway in her new paper entitled "Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway" in PNAS. Congratulations Sharon!
November 7, 2013
Malar Azagarsamy publishes "Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins" in Angewandte Chemie showing orthogonal photo-release of two different proteins using two wavelengths of light. Congratulations Malar!
October 14, 2013
Daniel McKinnon publishes "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems" in Advanced Materials. He developed a cytocompatible covalently adaptable hydrogel that enabled cell spreading and fusion and will allow future studies on the role of matrix biophysical properties on cell function.
July 28, 2013
Sharon Wang showed the unique gene expression profiles of several valvular interstitial subtypes. Her work will have deep impact in the heart disease community and showed that a certain subpopulation of cells participates in tissue repair and regeneration.
July 8, 2013
Jen Leight showed spatially resolved cellularly MMP activity through a FRET reporter peptide. She showed increased MMP expression in response to TGF-beta and higher substrate modulus. This is an excellent follow-up to her June Employee of the Month Award! Congratulations Jen!
July 8, 2013
Sarah Gould published a rad review of the role of matrix elasticity in aortic cell disease in Circulation Research. Congratulations Sarah!
S.T. Gould, S. Srigunapalan, C.A. Simmons, and K.S. Anseth, "Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease," Circulation Research (2013).