February 17, 2014
Nava showed the ability to reversibly exchange biochemical ligands using allyl sulfide-based living click strategies. Congratulations Nava!
N.R. Gandavarapu, M.A. Azagarsamy, and K.S. Anseth, "Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands," Advanced Materials (2014).
February 10, 2014
Chelsea Kirschner showed the ability to use microtopographies to dynamically modulate valvular interstitial cell fate. Congratulations Chelsea!
C.M. Kirschner, D.L. Alge, S.T. Gould, and K.S. Anseth, "Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype," Advanced Healthcare Materials (2014).
January 28, 2014
Sarah Gould's paper entitled "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation" demonstrates the essence of the interplay between VICs and VECs in maintaining a healthy valve phenotype. She further investigates the role of nitric oxide as a paracrine signaling molecule using a L-NAME, a soluble NO analog.
November 18, 2013
Nava showed that a5b1 integrin binding can induce osteogenic differentiation of hMSCs on stiff but not soft substrates. Congratulations Nava!
N.R. Gandavarapu, D.L. Alge and K.S. Anseth, "Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity," Biomaterials Science (2013).
November 12, 2013
Sharon Wang showed valvular interstitial cells respons to matrix elasticity through the PI3K/AKT pathway in her new paper entitled "Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway" in PNAS. Congratulations Sharon!
November 7, 2013
Malar Azagarsamy publishes "Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins" in Angewandte Chemie showing orthogonal photo-release of two different proteins using two wavelengths of light. Congratulations Malar!
October 14, 2013
Daniel McKinnon publishes "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems" in Advanced Materials. He developed a cytocompatible covalently adaptable hydrogel that enabled cell spreading and fusion and will allow future studies on the role of matrix biophysical properties on cell function.
July 28, 2013
Sharon Wang showed the unique gene expression profiles of several valvular interstitial subtypes. Her work will have deep impact in the heart disease community and showed that a certain subpopulation of cells participates in tissue repair and regeneration.