research

Jen Leight and Emi Tokuda publish "Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition" in PNAS

April 14, 2015

In this work, Jen (now at Ohio State) and Emi (now at Seattle Children's Hospital) investigate the effect of cancer drugs on matrix metalloproteinase (MMP) and metabolic activity of melanoma cells at various stages of metastasis. Their findings suggest that current clinical drugs can upregulate MMP activity, causing increased metastatic cell migration. Check out the pre-print publication here!

Katie Lewis publishes "In vitro model alveoli from photodegradable microsphere templates" in Biomaterials Science

April 2, 2015

In this work, Katie uses photodegradable hydrogel microparticles to create three dimensional cyst-like structures to mimic the native alveoli of the lung epithelium. Check it out here!

"Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition" accepted to Advanced Healthcare Materials.

January 30, 2015

In this paper, Balaji Sridhar demonstrates improved glycosaminoglycan and collagen deposition by co-encapsulating chondrocytes and MSCs in a functionalized cell-degradable PEG hydrogel. Check it out here!

"Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels" accepted to Soft Matter

October 11, 2014

This article, detailing a method for measuring the force of extending neurites, was recently accepted to Soft Matter and also invited for a cover art submission. An advance version is available here.

"Design and Characterization of a Synthetically Accessible, Photodegradable Hydrogel for User-Directed Formation of Neural Networks," by Daniel McKinnon and Tobin Brown accepted to ACS journal Biomacromolecules

June 16, 2014

Dan, Tobin, Kyle Kyburz, and undergraduate researcher Emi Kiyotake report on a photodegradable hydrogel for the co-culture of motor neurons and muscle cells. Confocal microscopy is used to erode three-dimensional channels allowing directed axon extension.

Coumarin based hydrogel

Malar Azagarsamy, Dan McKinnon, and Danny Alge publish "Coumarin-Based Photodegradable Hydrogel: Design, Synthesis, Gelation, and Degradation Kinetics" in ACS Macro Letters

May 16, 2014

Malar, Dan, and Danny show the gelation and degradation kinetics of a polymer network using coumarin as a new class of photodegradable crosslink. Micron-scale erosion was performed at wavelengths as long as 860 nm.

Samir Singh publishes "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" in Biomaterials Science

April 24, 2014

Samir Singh showed scaffold modulus and peptide functionalization affected tumor cell migration in a 3D synthetic matrix. His paper, entitled "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" appears in Biomaterials Science.

Daniel McKinnon and Dylan Domaille (Cha Lab) publish "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials

March 31, 2014

Daniel McKinnon and Dylan Domaille (postdoc in Jen Cha's lab) "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials.

Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials

March 17, 2014

Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials. She shows that hMSCs differentiate differently when exposed to surfaces of different moduli for different periods of time. Congratulations Chun!

Emi Tokuda publishes "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials

February 26, 2014

Emi Tokuda and Jen Leight published "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials showing the synergistic effect of matrix mechanics and melonoma drugs on cell response.

E.Y. Tokuda, J.L. Leight, and K.S. Anseth, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness," Biomaterials (2014).

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