research

"Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels" accepted to Soft Matter

October 11, 2014

This article, detailing a method for measuring the force of extending neurites, was recently accepted to Soft Matter and also invited for a cover art submission. An advance version is available here.

"Design and Characterization of a Synthetically Accessible, Photodegradable Hydrogel for User-Directed Formation of Neural Networks," by Daniel McKinnon and Tobin Brown accepted to ACS journal Biomacromolecules

June 16, 2014

Dan, Tobin, Kyle Kyburz, and undergraduate researcher Emi Kiyotake report on a photodegradable hydrogel for the co-culture of motor neurons and muscle cells. Confocal microscopy is used to erode three-dimensional channels allowing directed axon extension.

Coumarin based hydrogel

Malar Azagarsamy, Dan McKinnon, and Danny Alge publish "Coumarin-Based Photodegradable Hydrogel: Design, Synthesis, Gelation, and Degradation Kinetics" in ACS Macro Letters

May 16, 2014

Malar, Dan, and Danny show the gelation and degradation kinetics of a polymer network using coumarin as a new class of photodegradable crosslink. Micron-scale erosion was performed at wavelengths as long as 860 nm.

Samir Singh publishes "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" in Biomaterials Science

April 24, 2014

Samir Singh showed scaffold modulus and peptide functionalization affected tumor cell migration in a 3D synthetic matrix. His paper, entitled "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" appears in Biomaterials Science.

Daniel McKinnon and Dylan Domaille (Cha Lab) publish "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials

March 31, 2014

Daniel McKinnon and Dylan Domaille (postdoc in Jen Cha's lab) "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials.

Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials

March 17, 2014

Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials. She shows that hMSCs differentiate differently when exposed to surfaces of different moduli for different periods of time. Congratulations Chun!

Emi Tokuda publishes "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials

February 26, 2014

Emi Tokuda and Jen Leight published "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials showing the synergistic effect of matrix mechanics and melonoma drugs on cell response.

E.Y. Tokuda, J.L. Leight, and K.S. Anseth, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness," Biomaterials (2014).

Nava Gandavarapu publishes "Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands" in Advanced Materials

February 17, 2014

Nava showed the ability to reversibly exchange biochemical ligands using allyl sulfide-based living click strategies. Congratulations Nava!

N.R. Gandavarapu, M.A. Azagarsamy, and K.S. Anseth, "Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands," Advanced Materials (2014).

Chelsea Kirschner (currently at Sharklet) publishes "Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype" in Advanced Healthcare Materials

February 10, 2014

Chelsea Kirschner showed the ability to use microtopographies to dynamically modulate valvular interstitial cell fate. Congratulations Chelsea!

C.M. Kirschner, D.L. Alge, S.T. Gould, and K.S. Anseth, "Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype," Advanced Healthcare Materials (2014).

Sarah Gould's (currently at Novozymes) paper entitled "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation" published in Biomaterials

January 28, 2014

Sarah Gould's paper entitled "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation" demonstrates the essence of the interplay between VICs and VECs in maintaining a healthy valve phenotype. She further investigates the role of nitric oxide as a paracrine signaling molecule using a L-NAME, a soluble NO analog.

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