April 14, 2015
In this work, Jen (now at Ohio State) and Emi (now at Seattle Children's Hospital) investigate the effect of cancer drugs on matrix metalloproteinase (MMP) and metabolic activity of melanoma cells at various stages of metastasis. Their findings suggest that current clinical drugs can upregulate MMP activity, causing increased metastatic cell migration. Check out the pre-print publication here!
October 11, 2014
April 24, 2014
Samir Singh showed scaffold modulus and peptide functionalization affected tumor cell migration in a 3D synthetic matrix. His paper, entitled "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration" appears in Biomaterials Science.
March 31, 2014
Daniel McKinnon and Dylan Domaille (postdoc in Jen Cha's lab) "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of Materials.
March 17, 2014
Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials. She shows that hMSCs differentiate differently when exposed to surfaces of different moduli for different periods of time. Congratulations Chun!
February 26, 2014
Emi Tokuda and Jen Leight published "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials showing the synergistic effect of matrix mechanics and melonoma drugs on cell response.
E.Y. Tokuda, J.L. Leight, and K.S. Anseth, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness," Biomaterials (2014).