I am using tunable poly(ethylene glycol) hydrogels as a biomaterial to study the way cells behave under disease conditions. I use a variety of engineering and molecular biology approaches to study how cells respond to our materials. Our hydrogel system can simulate the real-time changes that occur during disease progression and recovery. I am culturing heart cells on surfaces that mimic features of healthy and diseased hearts, and we are measuring the cell’s biological and mechanical responses. This work will help engineers as well as basic scientists improve designs of engineered tissues and increase our knowledge of disease biology.
Wan W, Leinwand LA, Anseth KS., (2014) “Engineering the Cardiac Microenvironment Using a Tunable Hydrogel Cell Culture Platform,” 7th World Congress of Biomechanics, podium presentation
Wan W, Anseth KS, Leinwand LA., (2014) “A Dynamic Platform for Recapitulating Healthy and Diseased Cardiovascular Microenvironments,” Society for Biomaterials Annual Meeting, podium presentation
Wan, W., & Gleason, R. L. Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation. American journal of physiology. Heart and circulatory physiology, 304(5), H674–686, 2012.
Wan W, Dixon JB, Gleason RL. Constitutive Modeling of Mouse Carotid Arteries Using Experimentally Measured Microstructural Parameters. Biophysical Journal, 102(12), 2916-2925, 2012.