I am studying the deterioration of heart function due to disease. The inability of the heart to adequately pump blood throughout the body is the leading cause of death in Western societies. Stiffening of heart muscle is the primary cause of heart failure. I am growing cardiac muscle cells on biomaterials and changing the stiffness of the material as cells are growing on them. By changing the stiffness of the material, I can recreate the time-dependent changes in stiffness that occurs in diseased and healthy hearts. Using this system, I am attempting to determine ways to control the fate of cells so that they are more functional even under disease conditions. The knowledge gained in this project will help scientists and engineers improve designs of engineered heart tissue and increase the understanding of the progression of heart failure.
Wan, W., & Gleason, R. L. Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation. American journal of physiology. Heart and circulatory physiology, 304(5), H674–686, 2012.
Wan W, Dixon JB, Gleason RL. Constitutive Modeling of Mouse Carotid Arteries Using Experimentally Measured Microstructural Parameters. Biophysical Journal, 102(12), 2916-2925, 2012.
Maiellaro-Rafferty K, Weiss D, Joseph G, Wan W, Gleason RL, and Taylor WR. Catalase overexpression in aortic smooth muscle prevents pathological mechanical changes underlying abdominal aortic aneurysm formation. American Journal of Physiology - Heart and Circulatory Physiology 301(2): H355-H362, 2011.
Wan W, Hansen L, and Gleason RL. A 3-D constrained mixture model for mechanically mediated vascular growth and remodeling. Biomechanics and Modeling in Mechanobiology 9: 403-419, 2010.
Wan W, Yanagisawa H, and Gleason RL. Biomechanical and Microstructural Properties of Common Carotid Arteries from Fibulin-5 Null Mice. Annals of Biomedical Engineering 38: 1-13, 2010.
Hansen L, Wan W, and Gleason RL. Microstructurally-motivated constitutive modeling of mouse arteries cultured under altered axial stretch. Journal of Biomechanical Engineering 131: 11, 2009.
Zaucha M, Raykin J, Wan W, Gauvin, R, Auger F, Germain L, Gleason RL. “A Novel Biaxial Computer Controlled Bioreactor and Biomechanical Testing Device for Vascular Tissue Engineering.” Tissue Engineering Part A 15: 3331-3340, 2009.
Gleason RL, Wan W. Theory and Experiments for Mechanically-Induced Remodeling of Tissue Engineered Blood Vessels. Advances in Science and Technology (57) 226-34, 2008