Responsive polymers that critically change in properties in response to particular stimuli hold great promise for drug-delivery and controlled release applications. In the Anseth research group, I develop light responsive polymers for the controlled delivery of cells, proteins and siRNAs. Controlled delivery of multiple nutrients/drugs is a critical factor in the field of tissue engineering and regenerative medicine to grow different tissue types for the replacement of damaged ones. Light as an external source has become a powerful tool to achieve such delivery not only in a controlled manner and also in spatio-temporal fashion. Towards that, we have recently developed photodegradable nanogels for intracellular release of proteins and demonstrated the control over the protein activity using light (See Figure 1). In the similar line, we are currently developing click chemistry produced photodegradable materials that degrade at different wavelengths of single/two photon light (See Figure 2) for orderly release of two different proteins/cell types.
Azagarsamy, M. A.; Alge, D. L; Radhakrishan, S. J.; Tibbit M. W.; Anseth, K. S. “Photocontrolled Nanoparticles for Intracellular On Demand Release of Proteins” Biomacromolecules, 2012, ASAP
Azagarsamy, M. A.; Yesilyurt, V.; Thayumanavan. S. “Disassembly of Dendritic Amphiphilic Nanocontainers Due to Protein Binding” J. Am. Chem. Soc., 2010, 132, 4550.
Azagarsamy, M. A.; Sokkalingam, P.; Thayumanavan. S. “Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers” J. Am. Chem. Soc., 2009, 131, 14184.