Publications from the Lab

Cover Images:

  Cover

Wendy-Hanna Rose.        David Fay.              Dennis Eastburn.               Yu J. et al.            Mingxue Cui.          Marina Kniazeva.

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PUBLICATIONS:


From Last Century.

Han M. Ras proteins in developmental pattern formation in Caenorhabditis elegans and Drosophila. [Review]] Seminars in Cancer Biology. 3(4):219-28, 1992 Aug. Abstract
Han M. Golden A. Han Y. Sternberg PW. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature. 363(6425):133-40, 1993 May 13. Abstract
Sternberg PW. Golden A. Han M. Role of a raf proto-oncogene during Caenorhabditis elegans vulval development. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences. 340(1293):259-65, 1993 Jun 29.Abstract
Han, M. (1993). Ras-mediated signaling pathway during vulval development in C. elegans. Ciba Foundation symposium 176. The GTPase superfamily. pp. 215-217.
Han, M. (1994). Common themes in different lives. Book Review on Signal Transduction- Prokaryotic and Simple Eukaryotic Systems. Bioessays 16, 445-446.
Sternberg, P. and M. Han. (1994) Let-60 ras. Guidebook to the small GTPases. (Eds., L.A. Huber, M. Zerial and J. Tooze).
Wu Y. Han M. Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes & Development. 8(2):147-59, 1994 Jan.  Abstract
Wu Y. Han M. Guan KL. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes & Development. 9(6):742-55, 1995 Mar 15.  Abstract
Hara M. Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 92(8):3333-7, 1995 Apr 11.  Abstract
Singh N. Han M. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Genes & Development. 9(18):2251-65, 1995 Sep 15.  Abstract
Sundaram M. Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction . Cell. 83(6):889-901, 1995 Dec 15. Abstract
Sundaram M. Han M. Control and integration of cell signaling pathways during C. elegans vulval development. [Review] Bioessays. 18(6):473-80, 1996 Jun.
Sundaram M. Yochem J. Han M. A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development. 122(9):2823-33, 1996 Sep. Abstract
Han M. and M. Sundaram (1996) Ras-mediated signal transduction pathway in C. elegans. In: Regulation of the Ras Signaling Network (H. Maruta, ed.). R.G. Landes Company, pp. 47-74.
Zhang, K., Yen, H., Han, M. & Donoso, L. A. (1996) Molecular genetics of inherited macular dystrophies. British Journal of Ophthalmology. 80(11):1018-1022, 1996 Nov.
Yochem J. Sundaram M. Han M. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Molecular and Cellular Biology. 17(5):2716-2722, 1997 May. Abstract
Han M. Gut Reaction to Wnt Signaling in Worms. Cell. 90(4):581-584, 1997 Aug 22. Abstract
Sugimoto, T., Stewart, S., Han, M. and Guan, K-L (1997). The kinase suppressor of Ras (KSR) uncouples Elk-1 phosphorylation from MAP kinase activation. EMBO J17, 1717-1727.
Dent, J. and Han, M. (1998). Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs.  Mechanisms of Development.72, 179-182. Abstract
Gu, T. and Han, M. (1998) The C. elegans sur-5 gene negatively regulates let-60 ras activity and encodes an novel but evolutionarily conserved ATP binding protein. Mol. Cell. Biol.,18(8):4556-4564.
Kniazeva, M, Han, M. (1998). Addition of a second primer in PCR mixture after the first step of initial denaturation greatly improves synthesis of specific PCR fragments. TTO#1416, Elsevier Trends J., 1998
Yochem, J., Gu, T. and Han, M. (1998) Usage of SUR-5-GFP fusion protein as a marker to rapid DNA-mediated transformation and mosaic analysis in C. elegans. Genetics,149:1323-1334. Abstract
Sieburth, D., Qun, S., and Han, M.(1998) SUR-8,a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C.elegans. Cell. 94 (1):119-130. Abstract
Sternberg, P. and Han, M. (1998). Genetics of Ras Siganling in Caenorhabditis elegans. Trends in Genetics, 14 (11): 466-472. Abstract
Fay, D. S., Stanley, H., Han, M. and Wood, W. B. (1999) A Caenorhabditiselegans Homologue of hunchback is Required for Late Stages of Development but Not Early Embryonic Patterning.  Dev. Biol. 205, 204-253. Abstract
Hanna-Rose, W. and Han, M. (1999). Cog-2, a Sox domain protein necessary for establishing the functional connection between the uterus and the vulva in Caenorhabditis elegans. Development. 126 (1), 169-179. Abstract
Yochem, J. Tuch, S., Greenwald, I. and Han, M. (1999) A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development. 126 (3), 597-606. Abstract
Malone, C. J., Fixen, W. D., Horvits, H. R. and Han, M. (1999) UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development. 126, 3171-3181.
Kniazeva, M., Zawistovski, J., Han, M. (1998). Addition of a second primer in PCR mixture after the first step of initial denaturation greatly improves synthesis of specific PCR fragments. TTO#1416, Elsevier Trends Journals, 1998.
Zhang K, Garibaldi DC, Kniazeva M, Albini T, Chiang MF, Kerrigan M, Sunness JS, Han M, Allikmets R. (1999). A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease. Am J Ophthalmol. 128:720-4
Kniazeva, M., Chiang, M. F., Cutting, G. R.,  Han, M., Zhang, K. (1999) Clinical and genetic studies of an autosomal dominant cone-rod dystrophy with features of Stargardts disease. Ophthalmic Genetics 20, 71-81. Abstract
Kniazeva, M., Chiang, M. F., Han, M., Zhang, K. (1999)  A new gene forautosomal dominant Stargardt-like disease maps to chromosome 4. Amer. J. Hum. Gen. 64, 1394-1399.
Zhang K, Kniazeva M, Han M., Dean M, Allikmets R.  The ABCR Gene in Recessive and Dominant Stargardt Disease: A genetic Pathway in Macular Degeneration.  Genomics, 60(2):234-237, 1999.


2000
Kniazeva M, Traboulsi EI, Yu Z, Stefko ST, Gorin MB, Shugart YY, O'Connell JR, Blaschak CJ, Cutting G, Han M, Zhang K. (2000). A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. Am J Ophthalmol.  130:197-202.

Stewart, S., Sundaram, M., Zhang, Y., Lee, J., Xiong, Y. Han, M., and Guan, K-L. (1999). Kinase Suppressor of Ras (KSR) forms a multi-protein signaling complex and modulates MEK localization. MCB, 19, 5523-5534.
Li, W., Han, M. and Guan, K.L. (2000).  The Leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.  Gen & Dev.14, 895-900.

Fay, D.S. and Han, M. (2000). The Synthetic Multivulval Genes of C. elegans: Functional redundancy, Ras-antagonism, and cell fate determination. Genesis.  26, 279-284.

Grant, K, Hanna-Rose, W. and Han, M. (2000). Sem-4 promotes Caenorhabditis elegans vulval  fate determination through regulation of lin-39 hox. Devel. Biol.  224, 496-506.

Han, M. (2000). Studies on Ras-mediated signal transduction in C. elegans. In Sterm Cells and Development. Ed. By Jinseng Ye, Tian Xu, Tang Xifang and Bei
Haitial.  Medical Science Press. Beijing, China.

Chen, Z. and Han, M.(2000). Building a protein interaction map:research in the post-genomic era. BioEssays,22, 503-6.

Hanna-Rose, W. and Han, M. (2000). Getting your signal crossed. Curr. Opin. in Dev. Genetics. 10, 523-528.

Fay, D. S. and Han, M. (2000). Mutations in the C. elegans cyclin E gene reveal a timing mechanism that controls vulval cell differentiation. Development, 18,4049-4060.

2001
Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk, LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA,
Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K.  (2001). A 5bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genetics, 27, 89-93.

Yoder, J. and Han, M. (2001).  Cytoplasmic dynein light intermediate is required for discrete aspects of mitosis in Caenorhabditis elegans.  Mol. Cell. Biol  12, 2921-2933.

Chen, Z., Han, M. (2001)  Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis. Development. 128, 4911-4921.

Starr, D, Hermann, GJ., Malone, C. Fixsen, W., Priess, J. Horvitz, HR and Han, M. (2001). unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development.  128, 5039-5050.

Chen, Z. and Han, M. (2001). Role of Rb/E2F, the NuRD Complex, and Ras in Regulating a lin-39 Hox-mediated Cell Fusion Process during Vulval Fate Specification in C. elegans Curr. Biol. 11, 1874-1879.

Spencer, A., Orita, S., Malone, C., and Han, M. (2001) A RHO GTPase mediated pathway is required during P cell migration in C. elegans. Proc. Natl. Acd. Sci.  USA. 98, 13132-13137.


2002
Hanna-Rose, W. and Han, M. (2002). The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis.  Devel. Bio. 24, 247-258. (Cover illustration)

Antoshechkin, I. and Han, M. (2002). Caenorhabditis elegans evl-20 gene encodes a functional homologue of human small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Developmental Cell, 2, 579-591.

Starr, D. and Han, M. Role of ANC-1 in Tethering Nuclei to the Actin Cytoskeleton. Science. 298, 406-409.

Suzuki, Y., Morris, G., Han, M. and Wood, W.B. (2002). A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape. Genetics, in press.

Fay, D., Keneen, S. and Han, M. (2002)  fzr-1 and lin-35/Rb Function Redundantly to Control Cell Proliferation in C. elegans as Revealed by
Nonbiased Synthetic Screen. Genes & Dev. 16. 503-517. (Cover illustration)


2003
Fay D., Large, E. Han, M. and Darland, M. (2003) lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control
pharyngeal morphogenesis in C. elegans  Development.130, 3319-3330.

Kniazeva, M., Sieber, M. McCauley. S. Zhang, K. Watts, J., Han, M. (2003). Suppression of C. elegans ELO-2 function results in disruption of

palmitic acid elongation and causes multiple physiological defects including abnormal ultradian rhythms. Genetics, 163 159-169.

 

Starr, D and Han, M. (2003) ANChors away: an actin based mechanism of nuclear positioning. Journal of Cell Science. 15;116:211-6.

 

Cui, M. and Han. M. (2003) Cis Regulatory Requirements for Vulval Cell-Specific Expression of the Caenorhabditis elegans  Fibroblast Growth Factor Gene egl-17. Dev. Biol.  257, 104-116.

Wang, F., Yoder, J., Antoshechkin, I, and Han, M. (2003). C. elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in mitosis    and

meiosis. MCB, 23, 7698-7707.



2004
Yoder, J.H., Chong, H., Guan, K.L, and Han, M. (2004). Modulation of KSR activity in C . elegans by Zn ions, PAR-1 kinase and PP2A phosphatase,    EMBO J. 23, 111-119.

 

         Eastburn, D. and Han, M. (2004). When Ras Signaling Reaches the Mediator (2004). Developmental Cell. 6 158-159.

         Bourbon HM and 44 other authors (2004). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.  Mol Cell 14(5):553-557, 2004.

         Cui, M., Fay DS and Han, M. (2004). lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans Larval Development.  Genetics,  167, 1177-85

         Kniazeva, M. Crawford, QT, Seiber, M., Wang, C-Y and Han, M. (2004). Mono Methyl Branched Fatty Acids play essential role in C. elegans development. PLoS Biology, 2 (9),: e257.

         Chen, Z. Eastburn, D. and Han, M. (2004). C. elegans nuclear receptor nhr-25, regulates epidermal cell development.  MCB, 24, 7345-7358 (Cover photo).
 

         Li, W. Lee, J. Vikis, HG., Hoshino, A. Liu, G., Aurandts, J. Jiang, H., Fearon, ER., Han, M., Rao, Y., Hong, K., and Guan, K-L. (2004) Activation of FAK and Src are receptor proximal events required for netrin signaling. Nature Neuroscience, 7, 1213-1221.

 

2005

 

        *Grady, RM., *Starr, D, Ackerman, G. Sanes, JR., and Han, M. (2005). Syne proteins anchor muscle nuclei at the neuromuscular junction. PNAS,  102, 4359-64. (*co-first authors) (with mini-review).

 

         Del Campo, JJ., Opoku-Serebuoh, E. Issacson, AB., Tucker, M., Han, M. and Mohler WA. (2005) A single-protein fusogen in the somatic cells of C. elegans.  Current Biology, 15, 413-23.

 

Zhu, H. ,Xu, T. Han, M., Zhuang, Y. and Wu, X. (2005) Ubiquitous expression of mRFP1 in transgenic mice. Genesis. 2:86-90.

 

Starr, DA and Han, M. (2005). A genetic approach to study the role of nuclear envelope components in nuclear positioning.  Novartis Found   
         Symp. 264, 208-219.

 

         Ding, S., Wu, X., LI, G., Han, M., Zhuang, Y., and Xu, T (2005). Efficient Transition of PB transposon in mammalian cells and mice. Cell 122, 473-483. (Cover, featured article of the issue, Mini-review). 

 

         Ding, L., Spencer, A., Morita, K. and Han, M. (2005). The developmental timing regulator AIN-1 interacts with argonaute protein ALG-1, miRISCs and may target ALG-1 to cytoplasmic P bodies in C. elegans.  Mol. Cell. 19, 437-447 (featured article of the issue, Minireview in Dev Cell).

 

        Tucker, M., Sieburt M. Morphew M. and Han, M. (2005). The Caenorhabditis elegans aristaless orthologue, arl-1, is required for maintaining the functional and structural integrity of the amphid sensor organs. MBC, 16:4695-704 (Epub 7/29/05).

 

         Eastburn and Han, M. (2005) A gain-of-function allele of cbp-1 leads to an increase in HAT activity and antagonism of activated Ras.  MCB, 25:9427-34.

 

         Morita, K., Hirono, K. and Han, M. (2005) The C. elegans let-21/RhoGEF gene regulates the cytokinesis and migration of epidermal P cells. EMBO Report. 6, 1163-1168.

 

2006

 

         Ying, M., Xu, R., Wu, Xi, Zhuang, Y. Han, M. and Xu, T. (2006). Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. JBC, 281(18):12580-6.

 

        Suzuki, Y. and Han, M. Synthetic screen to uncover roles of daf-18/Pten in diverse processes during C. elegans development. (2006) Gen Dev 20(4):423-8.

 

        Cui M, Kim EB, Han M. Diverse Chromatin Remodeling Genes Antagonize the Rb-Involved SynMuv Pathways in C. elegans. PLoS Genet. 2006 May 19;2(5):e74

 

        Cui M, Chen J, Myers TR, Hwang BJ, Sternberg PW, Greenwald I, Han M. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate
vulval induction in C. elegans. Dev Cell. 2006 May;10(5):667-72.

 

Yu J, Starr DA, Wu X, Parkhurst SM, Zhuang Y, Xu T, Xu R, Han M.  The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during          Drosophila oogenesis. Dev Biol. 2006 Jan 15;289(2):336-45. Epub 2005 Dec 7.


Morita, K. and Han, M. (2006).  Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in C. elegans.     
 EMBO J.  13, 5794-5804.   

 

Eastburn, D. and Han, M. (2006). Ras signaling in C. elegans.  In Ras family GTPase, Protein and cell regulation volume 4.  Der, C. ed. Springer-sbm press. Pp192-226. 


Wan, M., Wu, X., Guan, K-L., Han, M., Zhuang, Y., and Xu, T. (2006). Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEB Lett. 580, 5621-7.



2007
Ding, Lei and Han, M. (2007) GW182 family proteins are critical players in miRNA-mediated gene silencing. Trends in Cell Biology.  Epub 8/31/07.

 

         Zhang, X, Xu, R., Zhu, B, Wu, X, Ding, X., Duang, S., Xu, T., Zhuang, Y. and Han, M. (2007). Syne-1 and Syne-2 play critical roles in myonuclear anchorage and
motor neuron innervation.  Development,134, 901-908.

 

         Cui, M. and Han, M.  Role of Chromatin factors in C. elegans.  A review chapter for Wormbook.com. WormBook, ed. The C. elegans Research Community,
WormBook, doi/10.1895/wormbook.1.139.1, http://www.wormbook.org.


         Ding, X., Xu, R., Yu., Xu., T. Zhuang, Y. and Han, M.  (2007) SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Developmental Cell  12, 863-872. (Editor’s Choice in Science, news reported in Nature Review Genetics).

Zhang, X, Xu, R., Zhu, B, Wu, X, Ding, X., Duang, S., Xu, T., Zhuang, Y. and Han, M. (2007). Syne-1 and Syne-2 play critical roles in myonuclear   anchorage and motor neuron innervation. Development, 134, 901-908. Three Faculty 1000 recommendations.

 

Zhang, L., Ding, L., Cheung, TH., Ding, M-Q., Chen, J., Sewell, AK., Liu, X., Yates III, JR., and Han, M. (2007), Systematic identification of miRISC proteins, miRNAs, and their mRNA targets in C. elegans by their interactions with GW182 family proteins AIN-1 and AIN-2. Mol Cell. 28, 598-613.Highlight in Nature Methods; Faculty of 1000 Recommendation.


2008

Sun LV, Jin K, Liu Y, Yang W, Xie X, Ye L, Wang L, Zhu L, Ding S, Su Y, Zhou J, Han M, Zhuang Y, Xu T, Wu X, Gu N, Zhong Y. (2008) PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res. 36, D729-34 (Epub ahead of print on 2007 Oct 11).

 

Sun, L., Wu, Xiaohui, Han, M. Xu, T. and Zhuang, Y. (2008). A Mitotic recombination system for mouse chromosome 17. PNAS, Epub on March 6.

 

Tucker, M. and Han, M. (2008). Muscle cell migrations of C. elegans are mediated by the -integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1. Dev Biol. 318, 215- 223.

 

Kniazeva, M., Euler, T. and Han, M. (2008). A branched-chain fatty acid is involved in postembryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback regulated in C. elegans. Genes Dev. 2008 22:2102-2110.  It was the Editor's choice paper Sci. Signal., 12 August 2008, vol.1 Issue 32, pec289.

 

Tian, L., Wu, X., Chi, C., Han, M., Xu., T, Zhuang, Y (2008) ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol. 20, 1181-7

Hammell, M. Long, D. Zhang, L., Lee, A. Han, M. Ding, Y. and Ambros. A. mirWIP: miRNA Target Prediction Based on miRNP Purified Targets. Nature Methods, 5, 813-819.

 

Cui, M. Aleen, M., Larsen, A., MacMorris, M. Han, M*. and Blumenthal, T. (2008). Genes involved in pre-mRNA 3’ end formation and transcription termination reveraled by a lin-15ABMuv suppressor screen. PNAS. In press.  *corresponding author.

Xu, X., Deng, K, Zhu Y., Wu, Y.  Ren, J., Wan, M. Zhao, S. Wu, X., Han, M., Zhuang, Y., Xu, T. A large-scale functional approach to uncover human genes and pathways in Drosophila.

         Cell Research (2008) 18:1114-1127.

 

 

2009

 Yu J, Ying M, Zhuang Y, Xu T, Han M, Wu X, Xu R. (2009) C-terminal deletion of the     atrophin-1 protein results in growth retardation but not neurodegeneration in mice. Dev Dyn.

           238(10):2471-8. PMID: 19681162

 

      Wu Y, Zhuang Y, Han M, Xu T, Deng K. (2009). Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. MC Dev Biol. 9:53. PMID: 19692642

 

      Dong Y, Du X, Ye J, Han M, Xu T, Zhuang Y, Tao W. (2009) A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol. 183:3865-72. PMID: 19692642

 

         Lei, K., Zhang, X. Ding, X., Guo, X., Chen, M., Zhu, B., Xu, T., Zhuang, Y., Xu, R. and Han, M. (2009). ­SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. PNAS. 106(25):10207-12. PMID: 19509342

 

      Seamen, E., Blanchette, JM, and Han, M. P-type ATPase (2009), TAT-2, negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans.  PLoS Genetics. 5(8):e1000589. PMID19662161

 

      Zhang, L., Hammmell, M., Kudlow, B., Ambros, V. and Han, M. (2009) Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development, 136:3043-55. PMID: 19675127. Accompanied with a highlight commentary in the same issue.

 

     Green, RM,  Gally F, Keeney JG, Alper S, Gao B, Han M, Martin RJ, Weinberger AR, Case SR, Minor MN, Chu HW. (2009). Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. PLoS One 4:e6860. PMID: 1971843

 

        Zhang, X., Lei, K., Yuan, X., Wu, Xi., Zhuang, Y., Xu, T. Xu, R. and Han, M. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron, 64, 173-187. PMID19874768. Accompanied with a Preview by Koizumi and Gleeson, Sun proteins enlighten nuclear movement in development. Neuron 64, 147-149.

 

       Tucker, M. and Han, M. (2009) Model Organisms for Human Disorders: Worm.  A chapter in Vogel and Motulsky’s Human Genetics, 4th ed. Eds, M. Speicher, S.E. Antonarakis, A. Motulsky, and G. Arno. Springer Berlin Heidelberg. Pp787-794. ISBN: 978-3-540-37653-8

 


2010

Kim S, Johnson W, Chen C, Sewell AK, Byström AS, Han M. (2010) Allele Specific Suppressors of lin-1(R175Opal) Identify Functions of MOC-3 and DPH-3 in tRNA Modification Complexes in C. elegans. Genetics. 185, 1235-1247. PMCID: PMC2927752.

 

Han, M. (2010). Advancing biology with a growing worm field.  Perspective article writing for a C. elegans special issue of Dev Dyn. 239, 1263-4. PMID: 20419781

 

Zhang, X and Han, M. (2010). Nuclear migration: rock and roll facilitated by dynein and kinesin. Current Biology. 20, 1027-9. PMID: 21145020

 

Yi J, Chen M, Wu X, Yang X, Xu T, Zhuang Y, Han M*, Xu R (2010). Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn. 239:2005-13. PMID: 20549726. (*co-corresponding author)

 

Lee, K-Z, Kniazeva, M., Han, M., Pujol, N., and Ewbank,J. (2010). The fatty acid synthase fasn-1 acts upstream of WNK/Ste20 and GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Virulence 1(3):111-2. PMCID: PMC3073241.

 

Chi, C., Zhu, H., Han, M., Zhuang, Y., Wu, X. and Xu, T. (2010). Disruption of lysosome function promotes tumor growth and metastasis in drosophila. JBC, 285, 21817-21823. PMID: 20418542

 

Zhang, C. L Tian, C Chi, X Wu, X Yang, M Han, T Xu, Y Zhuang, K Deng (2010). - Adam10 is essential for early embryonic cardiovascular development.
 Dev Dyn 239, 2594-2602 (2010).

 

        TEXT BOOK CHAPTER:

Han, M.  C. elegans genetics.  A chapter for the online Genetics textbook by Virtual Text (ergito.com).


2011

Zhang, X., Zabinsky, R., Teng, Y., Cui, M. and Han, M. (2011). miRNAs Play Critical Roles in the Survival and Recovery of C. elegans from Starvation-induced L1 Diapause. PNAS 108, 17997-8002.

 

Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M. (2011). KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 20:1061-73. Epub 2010 Dec 21. PMID: 21177258

 

Guo, Z., H Li, M Han, T Xu, X Wu, Y Zhuang (2011). Modeling Sj?gren's syndrome with Id3 conditional knockout mice.
 - Immunol Lett 135(1-2),34-42.

2012 (so far)

Kniazeva, M., Shen, H., Euler, T. and Han. M. (2012). Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev. 26:554-566. (Cover and Highlight).

 

Wu, X. Shi, Z., Cui, M., Han, M. and Ruvkun, G. (2012). Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genetics. e1002542.

 

Kudlow BA, Zhang, L. and Han M. (2012). Systematic Analysis of Tissue-Restricted miRISCs Reveals a Broad Role for microRNAs in Suppressing Basal Activation of the C. elegans Pathogen Response.  Mol Cell  In press.

 

Previous Min Han's Publications

Funding Sources of the Han Lab