- Ph.D., Chemical Engineering, University of California, Davis, 2003
- B.S., Chemical Engineering, University of Arizona, Tucson, 1999
- NSF CAREER Award, 2010
- NIH R21 Exploratory/Developmental Research Grant Award, 2009
- James D. Watson Investigator Award, 2008
- NIH R01 Bioengineering Research Grant Award, 2008
- Molecular imaging
- Targeted drug/gene delivery
Our research focuses on the design and engineering of colloidal theranostic (therapy + diagnostic) devices for medical imaging and therapy. We draw from more fundamental research in colloid science and soft materials to create novel agents applied to medical imaging and drug delivery. We are particularly interested in colloids that can be targeted to specific disease sites, enabling molecular imaging and controlled release.
Specifically, we are developing microbubbles for ultrasound imaging and targeted drug delivery. Examples include (1) ultrasound contrast agents for molecular imaging of tumor angiogenesis, (2) vehicles for DNA delivery to solid tumors, and (3) micro-capsules for intravenous injection of oxygen into hypoxic tissue.
- Feshitan JA, Vlachos F, Sirsi SR, Konofagou EE, Borden MA*. (2012). “Theranostic Gd(III)-lipid microbubbles for MRI-guided focused ultrasound surgery.” Biomaterials, 33:247-255.
- Sirsi SR, Hernandez S, Zielinski L, Blomback H, Koubaa A, Synder M, Homma S, Kandel JJ, Yamashiro DJ, Borden MA*. (2012). “Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors.” Journal of Controlled Release, 157:224–234. COVER STORY.
- Chen CC, Sirsi SR, Borden MA*. (2012). “Effect of surface architecture on in vivo ultrasound contrast persistence of targeted size-selected microbubbles.” Ultrasound in Medicine and Biology, 38:492-503.
- Flexman ML, Vlachos F, Kim HK, Sirsi S, Huang J, Hernandez SL, Johung TJ, Gander J, Reichstein A, Lampl BS, Wang A, Borden MA, Yamashiro DJ, Kandel JJ, Hielscher HJ*. (2012). “Monitoring Early Tumor Response to Drug Therapy with Diffuse Optical Tomography.” Journal of Biomedical Optics, 17:016014.
- Kwan, Borden*. (2012). “Lipid monolayer mechanics during microbubble gas exchange.” Soft Matter. 8:4756-4766.
- Sirsi SR, Flexman M, Vlachos F, Huang J, Hernandez SL, Kim HK, Johung TJ, Gander J, Reichstein A, Lampl BS, Wang A, Hielscher AH, Yamashiro DJ, Kandel JJ, Borden MA*. (2012). “Contrast ultrasound allows identification of early responder tumor models to anti-angiogenic therapy.” Ultrasound in Medicine and Biology. 38:1019–1029.
- Kheir JN*, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black K, Velazquez LA, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. (2012). “Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery.” Science Translational Medicine. 4:140ra88.
- Thomas, Looney, Butler, McDicken, Anderson, Emmer, Vos, de Jong, Borden, Stride, Pelekasis, Sboros. (2012). “The “quasi-stable” lipid shelled microbubble in response to consecutive ultrasound pulses.” Applied Physics Letters. Volume 101: article 071601.
- Kwan, Borden*. (2012). “Lipid monolayer collapse and microbubble stability.” Advances in Colloid & Interface Science. 183–184:82–99.
- Kwan, Kaya, Borden, Dayton*. (2012). “Theranostic oxygen delivery with ultrasound.” Theranostics. 2(12):1174-1184.