Our goal is to understand how cells safe-guard their genetic information. We want to know how they do this during their normal course of life as well as when they become exposed to external insults like radiation that can damage DNA. Loss of genetic information can result in death and disease. By understanding how cells safe-guard their genetic information, we may help prevent or treat diseases that result from loss of genetic information such as cancer.

We use Drosophila melanogaster (fruit fly) in our studies because it is a good model for human biology (read more about this).

Current projects:

1. Understanding how dWee1 kinase regulates a microtubule motor during mitosis (Kristin Garcia).
2. The role of checkpoint kinases in ensuring survival of cells, organs and organisms after exposure to X-rays (Lyle Uyetake)
3. Mechanism of p53-independent apoptosis after irradiation (Anita Wichmann).
4. A screen for radiation sensitizers (Tin Tin & undergraduates).