Understanding gene regulatory networks.

One of the most daunting tasks in biology understanding the regulatory interactions and dynamics involved in the living state. 

 
These regulatory networks are able to resist perturbation, but once directed into a specific trajectory, they "unfold" to produce complex patterns of cellular behavior leading to the patterning of the embryo, as well as tissue and organ formation.
 

Just keeping track of gene interactions in a way that facilitates the design of informative experiments and the interpretation of data can be difficult. 

We have been inspired by the work of Eric Davidson and colleagues on the regulatory networks in the sea urchin, and we are using their Biotapestry program to generate the maps shown here.


As part of projects funded by the American Heart Association and the National Institutes of Health, we have generated this site as a tool to present data on gene regulatory networks associated with early embryonic, neuroectodermal and neural crest patterning and cardiogenesis in the clawed frog Xenopus . 

If you have kudos, criticisms, comments,
additions, or suggested revisions, let us know. 

 

Network diagrams built using
last update: 07-Nov-2005