Lecture 15: Tetrad Analysis, Gene Mapping in Prokaryotic Organisms.
1. Briefly describe two experimental systems in which all of the products of a single meiosis can be recovered. How are such systems used in genetic mapping?
2. Explain how the centromere is used as a genetic marker when analyzing patterns of crossing over in Neurospora
3. What are the major differences in life cycles between the two types of yeast that are widely used in genetic research?
4. What is meant by the term "tetrad" and why is tetrad analysis of importance in genetic research?
5. Distinguish between ordered and unordered ascospores and explain how each can be used in genetic research.
6. Explain how a single crossover can generate either a 2:2:2:2 pattern or a 2:4:2 pattern in the ascospores of Neurospora.
7. Briefly describe the life cycle of Chlamydomonas and explain how it can be used for tetrad analysis.
8. Why is a tetratype with four different types of spores a more common occurence than a non-parental ditype, which has only two different types of spores?
9. What are the advantages of doing tetrad analysis with Neurospora ? What are the limitations of such studies?
10. What special values does tetrad analysis bring to genetics. What can be done with it that cannot readily be done with Drosophila or peas?
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