Date: Tue Jan 30 06:09:43 MST 2001
From: Mark Winey
Comment: Molly - We'll cover the information needed to answer question 3 on Wednesday. We did discuss the topic of pathway analysis a bit on Monday with respect to dog coat color.
Date: Tue Jan 30 12:43:06 MST 2001
From: David
Comment: Where can I find problem set #2?
Date: Tue Jan 30 14:12:21 MST 2001
From: Mark Winey
Comment: David - We should have access to the problem set on the web site fixed shortly. It is also available in the help room.
Date: Tue Jan 30 15:32:23 MST 2001
From: Christi L. MacRae
Comment: For question #5, are we supposed to assume no involvement of the Bombay phenotype?
Date: Tue Jan 30 15:33:23 MST 2001
From: Christi L. MacRae
Comment: oops...I meant question #4...
Date: Tue Jan 30 15:41:24 MST 2001
From: Mark Winey
Comment: Christi - The bombay allele is very rare. In doing human genetics problems assume wild-type unless told otherwise.
Date: Tue Jan 30 17:36:09 MST 2001
From: Dawn
Comment: Is problem set 2 going to be available tonight?
Date: Tue Jan 30 18:48:22 MST 2001
From: Dawn
Comment: Nevermind, I was just able to bring it up. Thanks!!
Date: Tue Jan 30 21:25:13 MST 2001
From: Dan
Comment: Dr. Winey, for #4, do we assume that blood type is made up of 1 gene with three alleles (Ia, Ib, Io) or that blood type is determined by 2 genes, with the second gene responsible for "substance H"- Like the Bombay phenotype example in the book?
Date: Tue Jan 30 22:29:19 MST 2001
From: Jessica
Comment: For #5, I suppose that we assume individuals with the hh allele display a pheonotype that is considered to be type O. From the parents, there is no way that a child can be a true type O (H-IoIo). Basically, do we assume that the geneotype hh- is like being a type O phenotype?
Date: Wed Jan 31 08:14:31 MST 2001
From: Mark Winey
Comment: Dan - Please see the answer to Christi above, "Christi - The bombay allele is very rare. In doing human genetics problems assume wild-type unless told otherwise." The rest of the answer to your question is that blood type is always controlled by H and I (and others), but people are almost always HH, so don't consider the contribution of this gene unless you're told to or have evidence that you need to consider it.
Date: Wed Jan 31 08:18:12 MST 2001
From: Mark Winey
Comment: Jessica - Yes, hh present the O phenotype even though you know that there is a molecular difference between hh and IoIo individuals, the phenotype is still O.
Date: Wed Jan 31 08:21:02 MST 2001
From: Mark Winey
Comment: Dan - I tried to e-mail you the above comment, but the message came back. For everyone - please be careful entering your e-mail address because I will send you the answer (assuming the address works).
Date: Wed Jan 31 08:21:03 MST 2001
From: Mark Winey
Comment: Dan - I tried to e-mail you the above comment, but the message came back. For everyone - please be careful entering your e-mail address because I will send you the answer (assuming the address works).
Date: Wed Jan 31 16:28:27 MST 2001
From: susan
Comment: Is O blood type dominant? What I mean is if a person is IaIo HH, are they A blood type or O blood type?
Date: Wed Jan 31 16:49:56 MST 2001
From: Gen
Comment: ON question #2, there are two possible outcomes of phenotypic ratios depending on the genotype of the black used from the F1 progeny.. are we supposed to give both possible outcomes? i.e. for each possible original genotype?
Date: Wed Jan 31 17:04:43 MST 2001
From: Gen
Comment: susan - i think that they would be A bloodtype. If the HH were hh, then it would display the O phenotype.
Date: Wed Jan 31 18:57:40 MST 2001
From: Katie
Comment: In #5 are we supposed to take into account the Bombay factor? Are we only supposed to give the ratio for "true" O, or for both the genotypes IoIo and hh, which yield the same phenotype of O blood type? Basically, is Bombay O a player in the probability?
Date: Wed Jan 31 19:56:27 MST 2001
From: Mark Winey
Comment: Katie - The question asks for the probability of children with O blood-type - that's a phenotype. If you can get it with various genotypes, so be it. Then you need to figure those various genotypes into the answer.
Date: Wed Jan 31 19:59:24 MST 2001
From: Mark Winey
Comment: Susan - Please refer to our fourth lecture. ABO blood-type is an example of multiple alleles, where A and B are codominant with each other, but both are dominant to O. Be careful about the epistatic Bombay phenotype from hh.
Date: Wed Jan 31 20:05:14 MST 2001
From: Mark Winey
Comment: Gen - Thanks for your correct answer to Susan. As for question 2 be very careful. The parents used in the 3 crosses in question 1 are true-breeding. Therefore the F1 progeny you are told to use in question 2 should have only one possible genotype (we followed the rules), so the cross you're asked to do in question 2 will yield only one answer.
Date: Wed Jan 31 22:06:46 MST 2001
From: Bill
Comment: I'm confused on what is meant by the answer format for questions 2,7 and 9. "Number Phenotype:Number of Phenotype: ETC" sounds like gibberish to me. does that mean "3 tan:1 red" (for example) is the right format, or is it supposed to be numbers only?
Date: Thu Feb 1 04:57:23 MST 2001
From: Mark Winey
Comment: Bill - Exactly right, we want the format of the answer to be in the 3 tan: 1 red format.
Date: Thu Feb 1 16:30:22 MST 2001
From: Brian Christenson
Comment: In question #7 how do we know which genotype of the red flowered plant is crossed with the true breeding purple flowered plant? Aern't there three different genotypes for the red plant?
Date: Thu Feb 1 19:59:43 MST 2001
From: Katie
Comment: I have trouble logging OFF of webCT, even if I close the browser when I get back on and choose "Log onto WebCT" it goes directly to mine. Is there a LOGOFF button?
Date: Thu Feb 1 20:22:17 MST 2001
From: Mark Winey
Comment: Katie - I don't know if there is a logoff button. Have you just closed the navigator window and opened it again, or have you quit the browser and relaunched it. You must quit the browser.
Date: Thu Feb 1 20:24:53 MST 2001
From: Mark Winey
Comment: Brian - Yes, several genotypes will give red plants. However, remember that the parental plants are true-breeding. Also, use the information from question 8 to figure out the genotype.
Date: Thu Feb 1 21:34:24 MST 2001
From: stephen
Comment: for the last questions. arent mmrr and mmRR both true breeding RED plants? which one do we use?
Date: Fri Feb 2 10:18:46 MST 2001
From: Mark Winey
Comment: Stephen - We went over it in class today, but only rrMM fulfills the information in question 8 where mating to magenta yields only purple plants. In my question writing, I write series of questions that are internally consistent such that the crosses are being done all come out correctly.