Updated 4/30/2008 4:36 PM

ASEN 5016
SPACE LIFE SCIENCES

Spring 2008            T/Th 1100-1215        Room ECCS 1B14

Distance Learning access available via CAETE

 

Instructor: Dr. David Klaus

telephone: (303) 492-3525

email: klaus@colorado.edu

 

This course is primarily intended to familiarize engineering students with factors affecting living organisms (ranging from single cells to humans) in the reduced-gravity environment of space flight, including lunar and Martian surface conditions. Unique insight will be gained regarding engineering design requirements for spacecraft life support systems, space habitats and spacesuits, and biotechnology payloads. NASA programs associated with current human space flight and future exploration missions are reflected and identified throughout the lecture topics. Life support fundamentals, as they relate to basic human survival requirements, are covered initially. Next, the lectures turn to more detailed descriptions of the physiological adaptations that occur to people in space, with pertinent background information presented for each topic. Corresponding biomedical countermeasures needed to maintain crew health for long duration missions will also be discussed, with emphasis on future Moon and Mars exploration plans. Finally, the underlying biophysical mechanisms affected by gravity, along with experiment design criteria, will be addressed.

 

In addition to elaborating on the lecture material, a linked series of homework tasks is intended as a practical introduction to the process of journal publishing and research proposal writing, and includes peer review processes for each. The assignment begins with writing a short journal article on a relevant topic of your choice, participating as a peer reviewer for the editor, revising your draft per comments received, and submitting a final manuscript.  From this background, you will subsequently prepare a research grant proposal that builds on your selected topic (along with a CV and budget) and culminates in a mock review panel held on the last day of class. This end-to-end flow closely mimics the standard practice in the scientific community and is a valuable generic process to experience regardless of your specific research interests.

 


NOTES:

 

The final topics to be covered are now indicated in the lecture sequence below, notes will be posted a day prior as usual. 

 

Quiz 3/4 and the Mock Panel Review process as part of HW4, which will be discussed and assigned on the last day of class, are all that remain as far as deliverables for the semester.

 

Don’t forget, your revised HW 1 manuscript is due on Thursday 4/3.  I’ll be discussing the HW 3 proposal then too.

 

I am available from now through the end of the semester (5/2) to schedule an appointment to go over the T/F/Depends questions on exam 1 for the ‘points back’ offer.  Email me to set a time, Mondays and Fridays are best.  Doing so by phone for CAETE students is fine.

 

Also, send me a short email regarding significant figure usage and I’ll also give you that point back for those of you who lost one there.

 

Homework 2 instructions are now posted – see links to Evaluation Metrics and Instructions for Reviewers below

 

Deadline for HW2 submittal has been extended 2 days to Thurs 3/13 (3/20 for CAETE)

 

Please take a look at the upcoming lecture flow, the order has been revised slightly to accommodate guest lecturer schedules.  Be sure to read the corresponding chapter(s) in the textbook indicated with each lecture prior to class.

 


OFFICE HOURS:  drop in as available, or by appointment, Mondays or Fridays

 

GRADING POLICY NOTES

 

ADDITIONAL SYLLABUS NOTES

 


LECTURE TOPICS – order and topics subject to slight revision

Overview of Humans in Space

Course Overview & Historical Perspective on Human Space Flight

Space Flight Environmental Parameters

Basic Human Life Support Requirements

Respiration and the Oxygen Cascade

Nutrition – Ch. 8, & Temperature Regulation

a) Motor Control & b) Chronobiology

Physiology of Extravehicular Activity (EVA)Ch. 5

Human Performance in Space

Exam Review

 

Exam 1 – 2/14

Human Physiological Adaptations to Space Flight

Miscellaneous Human Physiological Responses to Space Flight

Operational Space MedicineCh. 12 (partial)

Skeletal SystemCh. 1

Muscular SystemCh. 4

a) Hormonal Regulation & b) Immunological Response

Neuro-Sensory System – Ch. 6 (balance) & Ch. 9 (motion sickness)

Radiation EffectsCh. 3

Cardiovascular SystemCh. 7

Exam Review – linked summary & cardio feedback loops

 

Exam 2 – 3/20

 

-- Spring Break Week --

Space Life Science Research

Summary of Current Biomedical CountermeasuresCh. 11 & 12 (partial)

Space Biology Experiment Design (& Proposal Writing)

Gravity Dependent Physical Processes

1g & 0g Analogs

Guest Speaker, Joe Tanner

Microbial Responses & Related Crew Health Issues

Space Biotechnology & Plant and Animal Research in Space

Course wrap up & Psycho-Sociological Aspects – Ch. 2

 

Mock Review Panel – Final Period Monday, May 5, 1:30 pm

 

GRADING       20% - Exam 1

20% - Exam 2

10% - Quizzes

 

20% - Homework 1, Review Article grade based on final ‘revised and resubmitted’ version following peer review

  5% - Homework 2, Journal Peer Review – your participation as a reviewer

20% - Homework 3, Research Proposal grade based on proposal submittal with consideration of reviewer comments

  5% - Homework 4, Proposal Peer Review – your participation as a reviewer and in the ‘Mock Panel Meeting’

 

HW1 Review Article (Instructions for Authors) assigned – 1/22

HW1 Topic Selection due – 1/29

HW3 Research RFP (Submission Guidelines) – 2/7

HW1 Bibliography List due – 2/12

HW1 Manuscript First Draft with Cover Letter (Sample) due – 2/26

HW2 Journal Peer Review Process (Evaluation Metrics) Assigned (Reviewer Instructions) – 3/4

HW3 Research Proposal NOI due – 3/6 (topic only)

HW2 Reviewer Comments / Score Sheets due – 3/11 extended to 3/13

HW2 Reviewer Comments / Interim Score Returned to Authors – 3/20

HW3 Proposal Budget and CV Discussion – 4/3

HW1 Final Manuscript (Revise & Resubmit Guidelines) due with Cover Letter (Sample) – 4/3

HW3 Research Proposal due (hardcopy and electronic) – 4/10

HW4 Proposal Review Process (Evaluation Metrics) assigned – 4/17

HW4 Reviewer Score Sheets due (hardcopy only) – 4/24

HW4 Proposal Review Panel assigned – 5/1

HW4 Mock Review Panel Meeting – Final Period

 

TEXT               Space Physiology” by Buckey, Oxford University Press, 2006

 

Suggested optional, ancillary references for additional information

 

“Textbook of Medical Physiology” 10th ed. Guyton and Hall, 2000

 “Fundamentals of Space Medicine” Clement, Kluwer Academic Press, 2003

 “Fundamentals of Aerospace Medicine,” 3rd ed., Dehart and Davis, 2002

 “Going Higher – Oxygen, Man and Mountains” 4th ed., Houston, 1998

“Space Physiology and Medicine,” 3rd ed., Nicogossian, Huntoon and Pool, 1994 (out of print, difficult to find)

“Bioastronautics Data Book,”2nd ed., Parker and West (eds.), NASA SP-3006, 1973 (1st ed., 1964, both are out of print, difficult to find)

 

 

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