Updated 5/3/2013 10:45 AM
ASEN 5016
SPACE
LIFE SCIENCES
Spring 2013
Tues/Thurs 2-3:15 pm
ECCS 1B12
Distance Learning access via
CAETE
Instructor: Dr.
David Klaus
telephone: (303) 492-3525
email: klaus@colorado.edu
This course is primarily intended to familiarize engineering students with factors affecting living organisms (ranging from single cells to humans) in the reduced-gravity environment of space flight, including lunar and Martian surface conditions. Unique insight will be gained regarding engineering design requirements for spacecraft habitats, life support systems and spacesuits, as well as space biology payloads. Life support fundamentals, as they relate to basic human survival requirements, are covered initially. Next, the lectures turn to more detailed descriptions of the physiological adaptations that occur to people in space, with pertinent background information presented for each topic. Corresponding biomedical countermeasures needed to maintain crew health for long duration missions will also be discussed, including future Moon and Mars exploration. Finally, the underlying biophysical mechanisms affected by gravity, along with experiment design criteria, will be addressed. Current events within NASA’s future exploration mission programs and the emerging commercial human space flight sector are reflected throughout the lecture topics.
To further elaborate on the lecture material presented in class, a series of integrated homework tasks provides a practical introduction to the process of journal article publishing and research proposal writing, including the peer review process used for each. The assignment begins with writing a short journal article on a relevant topic of your choice, participating as a peer reviewer for the editor, revising your draft per the review comments you receive back, and submitting a final manuscript. From this background, you will subsequently prepare a research grant proposal that builds on your selected topic (along with a CV and budget) and culminates in a mock review panel. This end-to-end flow closely mimics the standard practice in the scientific community and is a valuable generic process to experience regardless of your specific research interests.
BULLETIN BOARD
Paper on ‘Extreme Fluid Dynamics’ discussing the Radiometer -
pdf
2/27/13 in the news… ‘Inspiration Mars’ mission - http://www.wired.com/wiredscience/2013/02/inspiration-mars-foundation/
Here is an example of the multiple steps in the publishing
process for a mini-review article that I wrote a few years ago. You can see the same general flow from
initial submittal to final accepted version and the basic outline of
introduction, detailed reviews, and a summary as specified for your HW1
assignment. Note that the superscript format for citing references differs here, be sure to follow the instructions for HW1.
1-guidelines
for submittals from the journal
2-partial
annotated bibliography compiled fall 2004/spring 2005
3-original
manuscript submission 5-16-05
4-cover
letter addressing peer review comments 9-23-05
5-revised
manuscript (changed as described above) 9-23-05
6-cover
letter with additional editorial changes summarized 12-9-05
7-revised
final draft submitted – 12-9-06
8-galley
proof corrections summarized 1-12-06
9-article
in print March 2006
Here is the article on balance and aging - pdf
OFFICE HOURS: Mon 2:30-3:30 and Weds 1:30-2:30
LECTURE TOPICS – order and topics subject to slight
revision
Course Overview & Historical Perspectives on Human Space Flight
Relevant Space Flight Environmental Parameters
Human Spacecraft Life Support Requirements and Considerations
Respiration and the Oxygen Cascade
Gravity Dependent Physical Processes
Nutrition –
Ch. 8 & Temperature Regulation
Exam 1 – 2/14/13
Miscellaneous Human Physiological Responses to Space Flight
Physiology of Extravehicular Activity (EVA) – Ch. 5
Neuro-Sensory System – Ch. 6 (balance) & Ch. 9 (motion sickness)
Hormonal Regulation & Immunological Response
Exam 2 – 3/21/2013
-- Spring Break Week 3/25-29
Space Biology Experiment Design & Proposal Writing
Summary of Current Biomedical Countermeasures – Ch. 11 & 12 (partial)
0g & 1g Analogs (Earth-based and Space-based)
Plant and Animal Research in Space
Microbial Responses & Related Crew Health Issues
Psycho-Sociological Aspects – Ch. 2
Operational Space Medicine – Ch. 12 (partial)
Astrobiology / Mock Review Panel prep
Mock Review Panel – Final Exam Period: Saturday May 4, 1:30 p.m. – 4:00 p.m.
GRADING 20%
- Exam 1
20% - Exam 2
10% - Quizzes (take home and in
class)
20% -
Homework 1, Review Article – grade based on final ‘revised and resubmitted’ version following
peer review
5% - Homework 2, Journal Peer Review – your participation as a
reviewer
20% -
Homework 3, Research Proposal – grade based on proposal submittal with consideration of reviewer
comments
5% - Homework 4, Proposal Peer Review – your participation as a reviewer and in the ‘Mock Panel Meeting’
HW1 Review Article (Instructions
for Authors) assigned – 1/22
HW1 Topic Selection due – 1/31
HW1 Annotated Bibliography / Working Title due –
2/12
HW3 Research RFP Released (Submission
Guidelines) assigned – 2/19
HW1 Manuscript Submittal (one hardcopy and
electronic file) with Cover Letter (in email body only) due – 2/26
HW2 Journal Peer Review Process (Reviewer Instructions) and (Evaluation Metrics) assigned – 2/28
HW2 Reviewer Comments / Score Sheets due – 3/7
HW3 Research Proposal NOI due – 3/12
HW2 Reviewer Comments / Interim Score Returned to
Authors – 3/14
HW3 Proposal Budget Prep (budget
template) and CV Discussion (see examples) – 4/2
HW1 Final Manuscript (Revise & Resubmit Instructions) with Cover Letter (see examples
posted at the top of this page) due 4/4 – extended to 4/9/13 (4/16 for CAETE)
HW3 Research Proposal (hardcopy and
electronic) due – 4/18
HW4 Proposal Review Process (Evaluation Metrics) assigned – 4/23
HW4 Reviewer Score Sheets (hardcopy
and electronic for local students, e-copy only for CAETE) due – 4/30
HW4 Mock Review Panel assigned – 4/30 (NOTE: for this exercise, CAETE students are on
the same schedule as the local class)
HW4 Mock Review Panel Meeting – Final Exam Period: Saturday May 4, 1:30 p.m. – 4:00 p.m.
TEXT “Space Physiology” by Buckey, Oxford University Press, 2006
Suggested optional, ancillary
references for additional information on this field of study
http://www.amazon.com/Stress-Challenges-Immunity-Space-Mechanisms/dp/3642222714#reader_3642222714
“Textbook of Medical Physiology” 12th ed. Guyton and Hall, 2011
“Fundamentals of Space Medicine” Clement, Kluwer Academic Press, 2003
“Fundamentals of Aerospace Medicine,” 4th ed., Dehart and Davis, 2008
“Going Higher – Oxygen, Man and Mountains” 4th ed., Houston, 1998
“Space Physiology and Medicine,” 3rd ed., Nicogossian, Huntoon and Pool, 1994 (out of print, difficult to find)
“Bioastronautics Data Book,”2nd ed., Parker and West (eds.), NASA SP-3006, 1973 (1st ed., 1964, both are out of print, difficult to find)
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